Attachment issues: kinetochore transformations and spindle checkpoint silencing

TY - JOUR

T1 - Attachment issues

T2 - kinetochore transformations and spindle checkpoint silencing

AU - Etemad, Banafsheh

AU - Kops, Geert Jpl

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/4

Y1 - 2016/4

N2 - Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetochores of all chromosomes are established. The anaphase inhibitor is generated at unattached kinetochores and inhibitor production is prevented when microtubules are captured. Understanding the molecular changes in the kinetochore that are evoked by microtubule attachments is crucial for understanding the mechanisms of SAC signaling and silencing. Here, we highlight the most recent findings on these events, pinpoint some remaining mysteries, and argue for incorporating holistic views of kinetochore dynamics in order to understand SAC silencing.

AB - Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetochores of all chromosomes are established. The anaphase inhibitor is generated at unattached kinetochores and inhibitor production is prevented when microtubules are captured. Understanding the molecular changes in the kinetochore that are evoked by microtubule attachments is crucial for understanding the mechanisms of SAC signaling and silencing. Here, we highlight the most recent findings on these events, pinpoint some remaining mysteries, and argue for incorporating holistic views of kinetochore dynamics in order to understand SAC silencing.

U2 - 10.1016/j.ceb.2016.02.016

DO - 10.1016/j.ceb.2016.02.016

M3 - Article

C2 - 26947988

SN - 0955-0674

VL - 39

SP - 101

EP - 108

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -