Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Abdullah M S Al-Hatmi; Abdullah Balkhair; Ibrahim Al-Busaidi; Marcelo Sandoval-Denis; Saif Al-Housni; Hashim Ba Taher; Asmaa Hamdan Al Shehhi; Sameer Raniga; Maha Al Shaibi; Turkiya Al Siyabi; Jacques F Meis; G Sybren de Hoog; Ahmed Al-Rawahi; Zakariya Al Muharrmi; Ahmed Al-Harrasi; Badriya Al Adawi

doi:10.3390/jof7080653

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

Abdullah M S Al-Hatmi, Abdullah Balkhair, Ibrahim Al-Busaidi, Marcelo Sandoval-Denis, Saif Al-Housni, Hashim Ba Taher, Asmaa Hamdan Al Shehhi, Sameer Raniga, Maha Al Shaibi, Turkiya Al Siyabi, Jacques F Meis, G Sybren de Hoog, Ahmed Al-Rawahi, Zakariya Al Muharrmi, Ahmed Al-Harrasi, Badriya Al Adawi

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

11 Citaten (Scopus)

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Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

Originele taal-2	Engels
Tijdschrift	Journal of Fungi
Volume	7
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.3390/jof7080653
Status	Gepubliceerd - 12 aug. 2021

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Al-Hatmi, A. M. S., Balkhair, A., Al-Busaidi, I., Sandoval-Denis, M., Al-Housni, S., Ba Taher, H., Al Shehhi, A. H., Raniga, S., Al Shaibi, M., Al Siyabi, T., Meis, J. F., de Hoog, G. S., Al-Rawahi, A., Al Muharrmi, Z., Al-Harrasi, A., & Al Adawi, B. (2021). Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis. Journal of Fungi, 7(8). https://doi.org/10.3390/jof7080653

@article{258260e61f774882834196c16d885b35,

title = "Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis",

abstract = "Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.",

author = "Al-Hatmi, {Abdullah M S} and Abdullah Balkhair and Ibrahim Al-Busaidi and Marcelo Sandoval-Denis and Saif Al-Housni and {Ba Taher}, Hashim and {Al Shehhi}, {Asmaa Hamdan} and Sameer Raniga and {Al Shaibi}, Maha and {Al Siyabi}, Turkiya and Meis, {Jacques F} and {de Hoog}, {G Sybren} and Ahmed Al-Rawahi and {Al Muharrmi}, Zakariya and Ahmed Al-Harrasi and {Al Adawi}, Badriya",

year = "2021",

month = aug,

day = "12",

doi = "10.3390/jof7080653",

language = "English",

volume = "7",

journal = "Journal of Fungi",

issn = "2309-608X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

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Al-Hatmi, AMS, Balkhair, A, Al-Busaidi, I, Sandoval-Denis, M, Al-Housni, S, Ba Taher, H, Al Shehhi, AH, Raniga, S, Al Shaibi, M, Al Siyabi, T, Meis, JF, de Hoog, GS, Al-Rawahi, A, Al Muharrmi, Z, Al-Harrasi, A & Al Adawi, B 2021, 'Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis', Journal of Fungi, vol. 7, nr. 8. https://doi.org/10.3390/jof7080653

TY - JOUR

T1 - Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

AU - Al-Hatmi, Abdullah M S

AU - Balkhair, Abdullah

AU - Al-Busaidi, Ibrahim

AU - Sandoval-Denis, Marcelo

AU - Al-Housni, Saif

AU - Ba Taher, Hashim

AU - Al Shehhi, Asmaa Hamdan

AU - Raniga, Sameer

AU - Al Shaibi, Maha

AU - Al Siyabi, Turkiya

AU - Meis, Jacques F

AU - de Hoog, G Sybren

AU - Al-Rawahi, Ahmed

AU - Al Muharrmi, Zakariya

AU - Al-Harrasi, Ahmed

AU - Al Adawi, Badriya

PY - 2021/8/12

Y1 - 2021/8/12

N2 - Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

AB - Human infectious fungal diseases are increasing, despite improved hygienic conditions. We present a case of gastrointestinal basidiobolomycosis (GIB) in a 20-year-old male with a history of progressively worsening abdominal pain. The causative agent was identified as a novel Basidiobolus species. Validation of its novelty was established by analysis of the partial ribosomal operon of two isolates from different organs. Phylogeny of ITS and LSU rRNA showed that these isolates belonged to the genus Basidiobolus, positioned closely to B. heterosporus and B. minor. Morphological and physiological data supported the identity of the species, which was named Basidiobolus omanensis, with CBS 146281 as the holotype. The strains showed high minimum inhibitory concentrations (MICs) to fluconazole (>64 µg/mL), itraconazole and voriconazole (>16 µg/mL), anidulafungin and micafungin (>16 µg/mL), but had a low MIC to amphotericin B (1 µg/mL). The pathogenic role of B. omanensis in gastrointestinal disease is discussed. We highlight the crucial role of molecular identification of these rarely encountered opportunistic fungi.

U2 - 10.3390/jof7080653

DO - 10.3390/jof7080653

M3 - Article

C2 - 34436192

SN - 2309-608X

VL - 7

JO - Journal of Fungi

JF - Journal of Fungi

IS - 8

ER -

Basidiobolus omanensis sp. nov. Causing Angioinvasive Abdominal Basidiobolomycosis

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