Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

TY - JOUR

T1 - Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

AU - Marsee, Ary

AU - Roos, Floris J M

AU - Verstegen, Monique M A

AU - Gehart, Helmuth

AU - de Koning, Eelco

AU - Lemaigre, Frédéric

AU - Forbes, Stuart J

AU - Peng, Weng Chuan

AU - Huch, Meritxell

AU - Takebe, Takanori

AU - Vallier, Ludovic

AU - Clevers, Hans

AU - van der Laan, Luc J W

AU - Spee, Bart

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2021/5/6

Y1 - 2021/5/6

N2 - Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

AB - Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

KW - Consensus

KW - Liver

KW - Organoids

KW - Pancreas

U2 - 10.1016/j.stem.2021.04.005

DO - 10.1016/j.stem.2021.04.005

M3 - Book/Film/Article review

C2 - 33961769

SN - 1934-5909

VL - 28

SP - 816

EP - 832

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -