Cancer stem cells revisited

Eduard Batlle; Hans Clevers

doi:10.1038/nm.4409

Cancer stem cells revisited

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

2000 Citaten (Scopus)

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The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.

Originele taal-2	Engels
Pagina's (van-tot)	1124-1134
Aantal pagina's	11
Tijdschrift	Nature Medicine
Volume	23
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1038/nm.4409
Status	Gepubliceerd - 06 okt. 2017

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abstract = "The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.",

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KW - Animals

KW - Cell Lineage

KW - Cell Plasticity

KW - Cell Self Renewal

KW - Drug Resistance, Neoplasm

KW - Epithelial-Mesenchymal Transition

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KW - Neoplasms

KW - Neoplastic Stem Cells

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Cancer stem cells revisited

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