Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

TY - JOUR

T1 - Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

AU - Hogan, B.M.

AU - Bos, F.L.

AU - Bussmann, J.

AU - de Witte, M.

AU - Chi, N.C.

AU - Duckers, H.J.

AU - Schulte-Merker, S.

N1 - Reporting year: 2009 Metis note: ng.321

PY - 2009

Y1 - 2009

N2 - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

AB - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

U2 - 10.1038/ng.321

DO - 10.1038/ng.321

M3 - Article

SN - 1061-4036

VL - 41

SP - 396

EP - 398

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -