Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba

H. Badali; M. Fernandez-Gonzalez; B. Mousavi; M.T. Illnait-Zaragozi; J.C. Gonzalez-Rodriguez; G.S. de Hoog; J.F.G.M. Meis

doi:10.1007/s11046-013-9634-3

Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba

H. Badali, M. Fernandez-Gonzalez, B. Mousavi, M.T. Illnait-Zaragozi, J.C. Gonzalez-Rodriguez, G.S. de Hoog, J.F.G.M. Meis

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 mug/ml), fluconazole (>64 mug/ml), anidulafungin (8 mug/ml) and caspofungin (8 mug/ml) were found.

Originele taal-2	Engels
Pagina's (van-tot)	439-444
Tijdschrift	Mycopathologia
Volume	175
Nummer van het tijdschrift	5-6
DOI's	https://doi.org/10.1007/s11046-013-9634-3
Status	Gepubliceerd - jun. 2013

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title = "Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba",

abstract = "We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 mug/ml), fluconazole (>64 mug/ml), anidulafungin (8 mug/ml) and caspofungin (8 mug/ml) were found.",

author = "H. Badali and M. Fernandez-Gonzalez and B. Mousavi and M.T. Illnait-Zaragozi and J.C. Gonzalez-Rodriguez and {de Hoog}, G.S. and J.F.G.M. Meis",

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doi = "10.1007/s11046-013-9634-3",

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T1 - Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba

AU - Badali, H.

AU - Fernandez-Gonzalez, M.

AU - Mousavi, B.

AU - Illnait-Zaragozi, M.T.

AU - Gonzalez-Rodriguez, J.C.

AU - de Hoog, G.S.

AU - Meis, J.F.G.M.

N1 - Reporting year: 2013

PY - 2013/6

Y1 - 2013/6

N2 - We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 mug/ml), fluconazole (>64 mug/ml), anidulafungin (8 mug/ml) and caspofungin (8 mug/ml) were found.

AB - We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 mug/ml), fluconazole (>64 mug/ml), anidulafungin (8 mug/ml) and caspofungin (8 mug/ml) were found.

U2 - 10.1007/s11046-013-9634-3

DO - 10.1007/s11046-013-9634-3

M3 - Article

SN - 0301-486X

VL - 175

SP - 439

EP - 444

JO - Mycopathologia

JF - Mycopathologia

IS - 5-6

ER -

Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba

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