Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Sjoerd J Klaasen; Geert J P L Kops

doi:10.3390/cells11223564

Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Boek/film/artikelrecensie › Wetenschappelijk

3 Citaten (Scopus)

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Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the origins of recurrent aneuploidy patterns in cancer and developing embryos. Here, we review recent progress in understanding the prevalence and causes of non-random chromosome segregation errors in mammalian mitosis and meiosis. We evaluate its potential impact on cancer and human reproduction and discuss possible research avenues.

Originele taal-2	Engels
Tijdschrift	Cells
Volume	11
Nummer van het tijdschrift	22
DOI's	https://doi.org/10.3390/cells11223564
Status	Gepubliceerd - 11 nov. 2022

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title = "Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis",

abstract = "Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the origins of recurrent aneuploidy patterns in cancer and developing embryos. Here, we review recent progress in understanding the prevalence and causes of non-random chromosome segregation errors in mammalian mitosis and meiosis. We evaluate its potential impact on cancer and human reproduction and discuss possible research avenues.",

keywords = "Animals, Humans, Meiosis/genetics, Mitosis/genetics, Chromosomes, Chromosome Segregation/genetics, Aneuploidy, Mammals/genetics",

author = "Klaasen, {Sjoerd J} and Kops, {Geert J P L}",

year = "2022",

month = nov,

day = "11",

doi = "10.3390/cells11223564",

language = "English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Chromosome Inequality

T2 - Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

AU - Klaasen, Sjoerd J

AU - Kops, Geert J P L

PY - 2022/11/11

Y1 - 2022/11/11

N2 - Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the origins of recurrent aneuploidy patterns in cancer and developing embryos. Here, we review recent progress in understanding the prevalence and causes of non-random chromosome segregation errors in mammalian mitosis and meiosis. We evaluate its potential impact on cancer and human reproduction and discuss possible research avenues.

AB - Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the origins of recurrent aneuploidy patterns in cancer and developing embryos. Here, we review recent progress in understanding the prevalence and causes of non-random chromosome segregation errors in mammalian mitosis and meiosis. We evaluate its potential impact on cancer and human reproduction and discuss possible research avenues.

KW - Animals

KW - Humans

KW - Meiosis/genetics

KW - Mitosis/genetics

KW - Chromosomes

KW - Chromosome Segregation/genetics

KW - Aneuploidy

KW - Mammals/genetics

U2 - 10.3390/cells11223564

DO - 10.3390/cells11223564

M3 - Book/Film/Article review

C2 - 36428993

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 22

ER -

Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

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