Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

Flore Sinturel; Simona Chera; Marie-Claude Brulhart-Meynet; Jonathan Paz Montoya; Dirk Jan Stenvers; Peter H Bisschop; Andries Kalsbeek; Idris Guessous; François R Jornayvaz; Jacques Philippe; Steven A Brown; Giovanni D'Angelo; Howard Riezman; Charna Dibner

doi:10.1016/j.xcrm.2023.101299

Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

Flore Sinturel, Simona Chera, Marie-Claude Brulhart-Meynet, Jonathan Paz Montoya, Dirk Jan Stenvers, Peter H Bisschop, Andries Kalsbeek, Idris Guessous, François R Jornayvaz, Jacques Philippe, Steven A Brown, Giovanni D'Angelo, Howard Riezman, Charna Dibner

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of lipid metabolism in subcutaneous white adipose tissue (SAT) and serum of type 2 diabetic (T2D) and non-diabetic (ND) human volunteers (n = 12). Around 8% of ≈440 lipid metabolites exhibit diurnal rhythmicity in serum and SAT from ND and T2D subjects. The spectrum of rhythmic lipids differs between ND and T2D individuals, with the most substantial changes observed early morning, as confirmed by lipidomics in an independent cohort of ND and T2D subjects (n = 32) conducted at a single morning time point. Strikingly, metabolites identified as daily rhythmic in both serum and SAT from T2D subjects exhibit phase differences. Our study reveals massive temporal and tissue-specific alterations of human lipid homeostasis in T2D, providing essential clues for the development of lipid biomarkers in a temporal manner.

Originele taal-2	Engels
Pagina's (van-tot)	101299
Tijdschrift	Cell reports. Medicine
Volume	4
DOI's	https://doi.org/10.1016/j.xcrm.2023.101299
Status	Gepubliceerd - 17 nov. 2023

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10.1016/j.xcrm.2023.101299

Sinturel2023Final published version, 5,3 MBLicentie: CC BY-NC-ND

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Sinturel, F., Chera, S., Brulhart-Meynet, M.-C., Montoya, J. P., Stenvers, D. J., Bisschop, P. H., Kalsbeek, A., Guessous, I., Jornayvaz, F. R., Philippe, J., Brown, S. A., D'Angelo, G., Riezman, H., & Dibner, C. (2023). Circadian organization of lipid landscape is perturbed in type 2 diabetic patients. Cell reports. Medicine, 4, 101299. https://doi.org/10.1016/j.xcrm.2023.101299

@article{fade0669421b4b0f9495d46a302d105b,

title = "Circadian organization of lipid landscape is perturbed in type 2 diabetic patients",

abstract = "Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of lipid metabolism in subcutaneous white adipose tissue (SAT) and serum of type 2 diabetic (T2D) and non-diabetic (ND) human volunteers (n = 12). Around 8% of ≈440 lipid metabolites exhibit diurnal rhythmicity in serum and SAT from ND and T2D subjects. The spectrum of rhythmic lipids differs between ND and T2D individuals, with the most substantial changes observed early morning, as confirmed by lipidomics in an independent cohort of ND and T2D subjects (n = 32) conducted at a single morning time point. Strikingly, metabolites identified as daily rhythmic in both serum and SAT from T2D subjects exhibit phase differences. Our study reveals massive temporal and tissue-specific alterations of human lipid homeostasis in T2D, providing essential clues for the development of lipid biomarkers in a temporal manner.",

author = "Flore Sinturel and Simona Chera and Marie-Claude Brulhart-Meynet and Montoya, {Jonathan Paz} and Stenvers, {Dirk Jan} and Bisschop, {Peter H} and Andries Kalsbeek and Idris Guessous and Jornayvaz, {Fran{\c c}ois R} and Jacques Philippe and Brown, {Steven A} and Giovanni D'Angelo and Howard Riezman and Charna Dibner",

year = "2023",

month = nov,

day = "17",

doi = "10.1016/j.xcrm.2023.101299",

language = "English",

volume = "4",

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TY - JOUR

T1 - Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

AU - Sinturel, Flore

AU - Chera, Simona

AU - Brulhart-Meynet, Marie-Claude

AU - Montoya, Jonathan Paz

AU - Stenvers, Dirk Jan

AU - Bisschop, Peter H

AU - Kalsbeek, Andries

AU - Guessous, Idris

AU - Jornayvaz, François R

AU - Philippe, Jacques

AU - Brown, Steven A

AU - D'Angelo, Giovanni

AU - Riezman, Howard

AU - Dibner, Charna

PY - 2023/11/17

Y1 - 2023/11/17

N2 - Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of lipid metabolism in subcutaneous white adipose tissue (SAT) and serum of type 2 diabetic (T2D) and non-diabetic (ND) human volunteers (n = 12). Around 8% of ≈440 lipid metabolites exhibit diurnal rhythmicity in serum and SAT from ND and T2D subjects. The spectrum of rhythmic lipids differs between ND and T2D individuals, with the most substantial changes observed early morning, as confirmed by lipidomics in an independent cohort of ND and T2D subjects (n = 32) conducted at a single morning time point. Strikingly, metabolites identified as daily rhythmic in both serum and SAT from T2D subjects exhibit phase differences. Our study reveals massive temporal and tissue-specific alterations of human lipid homeostasis in T2D, providing essential clues for the development of lipid biomarkers in a temporal manner.

AB - Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of lipid metabolism in subcutaneous white adipose tissue (SAT) and serum of type 2 diabetic (T2D) and non-diabetic (ND) human volunteers (n = 12). Around 8% of ≈440 lipid metabolites exhibit diurnal rhythmicity in serum and SAT from ND and T2D subjects. The spectrum of rhythmic lipids differs between ND and T2D individuals, with the most substantial changes observed early morning, as confirmed by lipidomics in an independent cohort of ND and T2D subjects (n = 32) conducted at a single morning time point. Strikingly, metabolites identified as daily rhythmic in both serum and SAT from T2D subjects exhibit phase differences. Our study reveals massive temporal and tissue-specific alterations of human lipid homeostasis in T2D, providing essential clues for the development of lipid biomarkers in a temporal manner.

U2 - 10.1016/j.xcrm.2023.101299

DO - 10.1016/j.xcrm.2023.101299

M3 - Article

C2 - 38016481

SN - 2666-3791

VL - 4

SP - 101299

JO - Cell reports. Medicine

JF - Cell reports. Medicine

ER -

Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

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