TY - JOUR
T1 - Coinfection of Pulmonary Hydatid Cyst and Aspergilloma
T2 - Case Report and Systematic Review
AU - Aliyali, M.
AU - Badali, H.
AU - Shokohi, T.
AU - Moazeni, M.
AU - Nosrati, A.
AU - Godazandeh, G.
AU - Dolatabadi, S.
AU - Nabili, M.
N1 - ISI Document Delivery No.: DG7UU Times Cited: 0 Cited Reference Count: 49 Aliyali, Masoud Badali, Hamid Shokohi, Tahereh Moazeni, Maryam Nosrati, Anahita Godazandeh, Gholamali Dolatabadi, Somayeh Nabili, Mojtaba School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran [123/94] This study was financially supported by a Grant (123/94) from the School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, which we gratefully acknowledge. The authors acknowledge Iman Haghani from Invasive Fungi Research Center (IFRC), Department of Medical Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, for helping in part of technical assistance. Springer Dordrecht
PY - 2016
Y1 - 2016
N2 - Aspergilloma infection consists of a mass of fungal hyphae, inflammatory cells, fibrin, mucus, and tissue debris and can colonize lung cavities due to underlying diseases such as tuberculosis, sarcoidosis, bronchiectasis, cavitary lung cancer, neoplasms, ankylosing spondylitis, bronchial cysts, and pulmonary infarction. Here we report coinfection of pulmonary hydatid cyst and aspergilloma in a 34-year-old female who had had history of minor thalassemia and suffered from chest pain, dyspnea, non-productive cough for at least five months, and hemoptysis for 20 days. Radiographic sign showed a large cavitary lesion (5 x 6 x 6 cm) involving left lower lobe (LLL). Dichotomous septate hyphae were observed in bronchoalveolar lavage and biopsy specimens from LLL. The patient subsequently improved after combined anti-helminth therapies with albendazole (400 mg/bd) and lobectomy. According to morphological and molecular characterization, Aspergillus niger was confirmed. In vitro antifungal susceptibility tests revealed that the MIC values for the antifungals used in this case in increasing order were posaconazole (0.125 A mu g/ml), itraconazole and voriconazole (0.5 A mu g/ml), and amphotericin B (1 A mu g/ml). The minimum effective concentration for caspofungin was 0.125 A mu g/ml. Subsequently, we systematically reviewed 22 confirmed cases of pulmonary hydatid cyst and aspergilloma during a period of 19 years (1995-2014) and discussed the epidemiology, clinical features, and treatment of this disease.
AB - Aspergilloma infection consists of a mass of fungal hyphae, inflammatory cells, fibrin, mucus, and tissue debris and can colonize lung cavities due to underlying diseases such as tuberculosis, sarcoidosis, bronchiectasis, cavitary lung cancer, neoplasms, ankylosing spondylitis, bronchial cysts, and pulmonary infarction. Here we report coinfection of pulmonary hydatid cyst and aspergilloma in a 34-year-old female who had had history of minor thalassemia and suffered from chest pain, dyspnea, non-productive cough for at least five months, and hemoptysis for 20 days. Radiographic sign showed a large cavitary lesion (5 x 6 x 6 cm) involving left lower lobe (LLL). Dichotomous septate hyphae were observed in bronchoalveolar lavage and biopsy specimens from LLL. The patient subsequently improved after combined anti-helminth therapies with albendazole (400 mg/bd) and lobectomy. According to morphological and molecular characterization, Aspergillus niger was confirmed. In vitro antifungal susceptibility tests revealed that the MIC values for the antifungals used in this case in increasing order were posaconazole (0.125 A mu g/ml), itraconazole and voriconazole (0.5 A mu g/ml), and amphotericin B (1 A mu g/ml). The minimum effective concentration for caspofungin was 0.125 A mu g/ml. Subsequently, we systematically reviewed 22 confirmed cases of pulmonary hydatid cyst and aspergilloma during a period of 19 years (1995-2014) and discussed the epidemiology, clinical features, and treatment of this disease.
KW - Coinfection Aspergilloma Hydatid cyst Hydatidosis Aspergillus species invasive fungal-infections surgical-treatment echinococcosis epidemiology fumigatus mycosis cavity
U2 - 10.1007/s11046-015-9974-2
DO - 10.1007/s11046-015-9974-2
M3 - Article
SN - 0301-486X
VL - 181
SP - 255
EP - 265
JO - Mycopathologia
JF - Mycopathologia
IS - 3-4
ER -