Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

S. Deng; W. Lei; G. S. de Hoog; L. Yang; R. G. Vitale; H. Rafati; M. Seyedmousavi; A. Tolooe; H. van der Lee; W. Liao; P. E. Verweij; S. Seyedmousavi

doi:10.1128/AAC00270-18

Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

S. Deng, W. Lei, G. S. de Hoog, L. Yang, R. G. Vitale, H. Rafati, M. Seyedmousavi, A. Tolooe, H. van der Lee, W. Liao, P. E. Verweij, S. Seyedmousavi

Westerdijk Fungal Biodiversity Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

Samenvatting

Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

Originele taal-2	Engels
Tijdschrift	Antimicrobial Agents and Chemotherapy
Volume	62
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1128/AAC00270-18
Status	Gepubliceerd - 01 jun 2018

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10.1128/AAC00270-18

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Citeer dit

Deng, S., Lei, W., de Hoog, G. S., Yang, L., Vitale, R. G., Rafati, H., Seyedmousavi, M., Tolooe, A., van der Lee, H., Liao, W., Verweij, P. E., & Seyedmousavi, S. (2018). Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis. Antimicrobial Agents and Chemotherapy, 62(6). https://doi.org/10.1128/AAC00270-18

@article{133f576c237d4fd3b81f3113341c7f1b,

title = "Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis",

abstract = " Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora . ",

keywords = "Amphotericin B, Chromoblastomycosis, Combination therapy, Melanized fungi, Terbinafine",

author = "S. Deng and W. Lei and {de Hoog}, {G. S.} and L. Yang and Vitale, {R. G.} and H. Rafati and M. Seyedmousavi and A. Tolooe and {van der Lee}, H. and W. Liao and Verweij, {P. E.} and S. Seyedmousavi",

year = "2018",

month = jun

day = "1",

doi = "10.1128/AAC00270-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "6",

}

Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis. / Deng, S.; Lei, W.; de Hoog, G. S.; Yang, L.; Vitale, R. G.; Rafati, H.; Seyedmousavi, M.; Tolooe, A.; van der Lee, H.; Liao, W.; Verweij, P. E.; Seyedmousavi, S.

In: Antimicrobial Agents and Chemotherapy, Vol. 62, Nr. 6, 01.06.2018.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

TY - JOUR

T1 - Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

AU - Deng, S.

AU - Lei, W.

AU - de Hoog, G. S.

AU - Yang, L.

AU - Vitale, R. G.

AU - Rafati, H.

AU - Seyedmousavi, M.

AU - Tolooe, A.

AU - van der Lee, H.

AU - Liao, W.

AU - Verweij, P. E.

AU - Seyedmousavi, S.

PY - 2018/6/1

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N2 - Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

AB - Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

KW - Amphotericin B

KW - Chromoblastomycosis

KW - Combination therapy

KW - Melanized fungi

KW - Terbinafine

U2 - 10.1128/AAC00270-18

DO - 10.1128/AAC00270-18

M3 - Article

C2 - 29581111

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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