Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

S. Deng, W. Lei, G. S. de Hoog, L. Yang, R. G. Vitale, H. Rafati, M. Seyedmousavi, A. Tolooe, H. van der Lee, W. Liao, P. E. Verweij, S. Seyedmousavi

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Samenvatting

Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

Originele taal-2Engels
TijdschriftAntimicrobial Agents and Chemotherapy
Volume62
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 01 jun 2018

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    Deng, S., Lei, W., de Hoog, G. S., Yang, L., Vitale, R. G., Rafati, H., Seyedmousavi, M., Tolooe, A., van der Lee, H., Liao, W., Verweij, P. E., & Seyedmousavi, S. (2018). Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis. Antimicrobial Agents and Chemotherapy, 62(6). https://doi.org/10.1128/AAC00270-18