Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

TY - JOUR

T1 - Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

AU - Deng, S.

AU - Lei, W.

AU - de Hoog, G. S.

AU - Yang, L.

AU - Vitale, R. G.

AU - Rafati, H.

AU - Seyedmousavi, M.

AU - Tolooe, A.

AU - van der Lee, H.

AU - Liao, W.

AU - Verweij, P. E.

AU - Seyedmousavi, S.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

AB - Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

KW - Amphotericin B

KW - Chromoblastomycosis

KW - Combination therapy

KW - Melanized fungi

KW - Terbinafine

U2 - 10.1128/AAC00270-18

DO - 10.1128/AAC00270-18

M3 - Article

C2 - 29581111

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -