Complexity of functional connectivity networks in mild cognitive impairment subjects during a working memory task

M Ahmadlou, Anahita Adeli, Ricardo Bajo, Hojjat Adeli

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

OBJECTIVES: The objective is to study the changes of brain activity in patients with mild cognitive impairment (MCI). Using magneto-encephalogram (MEG) signals, the authors investigate differences of complexity of functional connectivity network between MCI and normal elderly subjects during a working memory task.

METHODS: MEGs are obtained from 18 right handed patients with MCI and 19 age-matched elderly participants without cognitive impairment used as the control group. The brain networks' complexities are measured by Graph Index Complexity (C(r)) and Efficiency Complexity (C(e)).

RESULTS: The results obtained by both measurements show complexity of functional networks involved in the working memory function in MCI subjects is reduced at alpha and theta bands compared with subjects with control subjects, and at the theta band this reduction is more pronounced in the whole brain and intra left hemisphere.

CONCLUSIONS: C(e) would be a better measurement for showing the global differences between normal and MCI brains compared with C(r).

SIGNIFICANCE: The high accuracy of the classification shows C(e) at theta band can be used as an index for assessing deficits associated with working memory, a good biomarker for diagnosis of MCI.

Originele taal-2Engels
Pagina's (van-tot)694-702
Aantal pagina's9
TijdschriftClinical Neurophysiology
Volume125
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - apr. 2014

Vingerafdruk

Duik in de onderzoeksthema's van 'Complexity of functional connectivity networks in mild cognitive impairment subjects during a working memory task'. Samen vormen ze een unieke vingerafdruk.

Citeer dit