Considerations on vitamin D supplementation in multiple sclerosis

TY - CHAP

T1 - Considerations on vitamin D supplementation in multiple sclerosis

AU - Smolders, Joost

AU - Damoiseaux, Jan

N1 - Publisher Copyright: © 2023 Elsevier Inc. All rights reserved.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Vitamin D is the precursor of a steroid hormone with immune-modulating properties. Low circulating levels of the vitamin D metabolite 25-hydroxyvitamin D have been associated with a higher risk of disease activity in patients suffering from multiple sclerosis (MS), in terms of relapse risk and risk of MRI lesions. Additionally, several randomized controlled clinical trials, although mostly negative on primary endpoints, provided some indications for positive effects of vitamin D supplements on these endpoints. However, results of individual association studies and trials in MS are heterogeneous. In this chapter, we provide a discussion of these different studies. We explore several explanations for this heterogeneity and conclude with some implications for advises on vitamin D supplements for people with MS.

AB - Vitamin D is the precursor of a steroid hormone with immune-modulating properties. Low circulating levels of the vitamin D metabolite 25-hydroxyvitamin D have been associated with a higher risk of disease activity in patients suffering from multiple sclerosis (MS), in terms of relapse risk and risk of MRI lesions. Additionally, several randomized controlled clinical trials, although mostly negative on primary endpoints, provided some indications for positive effects of vitamin D supplements on these endpoints. However, results of individual association studies and trials in MS are heterogeneous. In this chapter, we provide a discussion of these different studies. We explore several explanations for this heterogeneity and conclude with some implications for advises on vitamin D supplements for people with MS.

KW - Clinical trials

KW - MRI

KW - Multiple sclerosis

KW - Relapses

KW - Supplementation

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85166139304&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-89835-5.00012-0

DO - 10.1016/B978-0-323-89835-5.00012-0

M3 - Chapter

AN - SCOPUS:85166139304

SN - 9780323915724

SP - 359

EP - 377

BT - Vitamins and Minerals in Neurological Disorders

PB - Elsevier

ER -