Controlling miRNA regulation in disease

TY - JOUR

T1 - Controlling miRNA regulation in disease

AU - Gommans, W.M.

AU - Berezikov, E.

N1 - Reporting year: 2012

PY - 2012

Y1 - 2012

N2 - Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype. KEYWORDS: Animals; Disease/genetics; Gene Expression Regulation; Humans; MicroRNAs/ genetics/ metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics/metabolism

AB - Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype. KEYWORDS: Animals; Disease/genetics; Gene Expression Regulation; Humans; MicroRNAs/ genetics/ metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics/metabolism

U2 - 10.1007/978-1-61779-427-8_1

DO - 10.1007/978-1-61779-427-8_1

M3 - Article

SN - 1064-3745

VL - 822

SP - 1

EP - 18

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

ER -