Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

Geert J P L Kops, Reto Gassmann

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveBoek/film/artikelrecensieWetenschappelijk

Samenvatting

The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.

Originele taal-2Engels
Pagina's (van-tot)653-667
Aantal pagina's15
TijdschriftTrends in Cell Biology
Volume30
Nummer van het tijdschrift8
DOI's
StatusGepubliceerd - aug 2020

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