TY - JOUR
T1 - Crowning the Kinetochore
T2 - The Fibrous Corona in Chromosome Segregation
AU - Kops, Geert J P L
AU - Gassmann, Reto
N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.
AB - The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.
U2 - 10.1016/j.tcb.2020.04.006
DO - 10.1016/j.tcb.2020.04.006
M3 - Book/Film/Article review
C2 - 32386879
SN - 0962-8924
VL - 30
SP - 653
EP - 667
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -