Cryptococcal meningitis in systemic lupus erythematosus patients: pooled analysis and systematic review

Wenjie Fang, Min Chen, Jia Liu, Ferry Hagen, Abdullah Ms, A M S Al-Hatmi, Peilian Zhang, Yun Guo, Teun Boekhout, Danqi Deng, Jianping Xu, Weihua Pan, Wanqing Liao

    Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

    Samenvatting

    Cryptococcal meningitis is an important fungal infection among systemic lupus erythematosus patients. We conducted a pooled analysis and systematic review to describe the epidemiological and clinical profile of cryptococcal meningitis in systemic lupus erythematosus patients. From two hospitals in China and nine literature databases, cases and prevalence data were collected for pooled analysis and meta-analysis, respectively. Categorical variables of cases were compared using a χ(2)-test on the statistical program of SAS. A multiple regression analysis was performed to ascertain independent predictors significantly correlated with prognosis. Meta-analysis was conducted by the statistical program of R. The prevalence of cryptococcal meningitis in systemic lupus erythematosus patients was 0.5%. Patients were predominantly females and adults. A prednisone equivalent of more than 30 mg/day before infection was associated with higher mortality (odds ratio (OR)=9.69 (1.54, 60.73)). In all, 36.8-38.9% patients showed low lupus activity when they developed the crytococcal infection. Moreover, 38.2% of the patients were misdiagnosed. The estimated case-fatality rate was 23.6%. Our results suggest that more emphasis should be placed to further understand lupus-related cryptococcal meningitis and to develop better prophylaxis and management strategies to combat this condition.

    Originele taal-2Engels
    Pagina's (van-tot)e95
    TijdschriftEmerging Microbes & Infections
    Volume5
    Nummer van het tijdschrift9
    DOI's
    StatusGepubliceerd - 07 sep. 2016

    Vingerafdruk

    Duik in de onderzoeksthema's van 'Cryptococcal meningitis in systemic lupus erythematosus patients: pooled analysis and systematic review'. Samen vormen ze een unieke vingerafdruk.

    Citeer dit