Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

Yorick Post, Hans Clevers

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.

Originele taal-2Engels
Pagina's (van-tot)174-183
Aantal pagina's10
TijdschriftCell Stem Cell
Volume25
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 01 aug 2019

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