Development of microRNA therapeutics is coming of age

Eva van Rooij; Sakari Kauppinen

doi:10.15252/emmm.201100899

Development of microRNA therapeutics is coming of age

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

470 Citaten (Scopus)

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MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

Originele taal-2	Engels
Pagina's (van-tot)	851-64
Aantal pagina's	14
Tijdschrift	EMBO Molecular Medicine
Volume	6
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.15252/emmm.201100899
Status	Gepubliceerd - jul. 2014

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10.15252/emmm.201100899Licentie: CC BY

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title = "Development of microRNA therapeutics is coming of age",

abstract = "MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.",

author = "{van Rooij}, Eva and Sakari Kauppinen",

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year = "2014",

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AB - MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

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Development of microRNA therapeutics is coming of age

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