Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice

P.E. Penttinen-Damdimopoulou; K.A. Power; T.T. Hurmerinta; T. Nurmi; P.T. van der Saag; S.I. Makela

doi:10.1002/mnfr.200800487

Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice

P.E. Penttinen-Damdimopoulou, K.A. Power, T.T. Hurmerinta, T. Nurmi, P.T. van der Saag, S.I. Makela

Hubrecht Institute

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29 Citaten (Scopus)

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Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and isoflavones (soy) was studied in vivo. Adult ovariectomized 3 x ERE-luciferase (luc) reporter mice received isocaloric diets supplemented with flaxseed, rye, wheat, or soy for 40 h or two weeks, and an additional group of mice was challenged with 17beta-estradiol (E(2)) following the two-week dietary intervention. In non-E(2)-treated mice, soy diet induced luc expression in liver, mammary gland, and pituitary gland while the other diets had no effects. Interestingly, all diets modulated the E(2)-induced luc expression. In particular rye diet efficiently reduced E(2)-induced luc expression as well as uterine growth, the hallmark of estrogen action in vivo. It is concluded that dietary sources of lignans and isoflavones can modulate estrogen signaling in vivo. The results suggest intriguing possibilities for the modulation of the risk of estrogen-dependent diseases by dietary means.

Originele taal-2	Engels
Pagina's (van-tot)	996-1006
Tijdschrift	Molecular nutrition & food research
Volume	53
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1002/mnfr.200800487
Status	Gepubliceerd - 2009

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10.1002/mnfr.200800487

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@article{4bd554ba0f9846d5894b37f02447f30d,

title = "Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice",

abstract = "Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and isoflavones (soy) was studied in vivo. Adult ovariectomized 3 x ERE-luciferase (luc) reporter mice received isocaloric diets supplemented with flaxseed, rye, wheat, or soy for 40 h or two weeks, and an additional group of mice was challenged with 17beta-estradiol (E(2)) following the two-week dietary intervention. In non-E(2)-treated mice, soy diet induced luc expression in liver, mammary gland, and pituitary gland while the other diets had no effects. Interestingly, all diets modulated the E(2)-induced luc expression. In particular rye diet efficiently reduced E(2)-induced luc expression as well as uterine growth, the hallmark of estrogen action in vivo. It is concluded that dietary sources of lignans and isoflavones can modulate estrogen signaling in vivo. The results suggest intriguing possibilities for the modulation of the risk of estrogen-dependent diseases by dietary means.",

author = "P.E. Penttinen-Damdimopoulou and K.A. Power and T.T. Hurmerinta and T. Nurmi and {van der Saag}, P.T. and S.I. Makela",

note = "Reporting year: 2009",

year = "2009",

doi = "10.1002/mnfr.200800487",

language = "English",

volume = "53",

pages = "996--1006",

journal = "Molecular nutrition & food research",

issn = "1613-4125",

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Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. / Penttinen-Damdimopoulou, P.E.; Power, K.A.; Hurmerinta, T.T. et al.
In: Molecular nutrition & food research, Vol. 53, Nr. 8, 2009, blz. 996-1006.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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T1 - Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice

AU - Penttinen-Damdimopoulou, P.E.

AU - Power, K.A.

AU - Hurmerinta, T.T.

AU - Nurmi, T.

AU - van der Saag, P.T.

AU - Makela, S.I.

N1 - Reporting year: 2009

PY - 2009

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N2 - Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and isoflavones (soy) was studied in vivo. Adult ovariectomized 3 x ERE-luciferase (luc) reporter mice received isocaloric diets supplemented with flaxseed, rye, wheat, or soy for 40 h or two weeks, and an additional group of mice was challenged with 17beta-estradiol (E(2)) following the two-week dietary intervention. In non-E(2)-treated mice, soy diet induced luc expression in liver, mammary gland, and pituitary gland while the other diets had no effects. Interestingly, all diets modulated the E(2)-induced luc expression. In particular rye diet efficiently reduced E(2)-induced luc expression as well as uterine growth, the hallmark of estrogen action in vivo. It is concluded that dietary sources of lignans and isoflavones can modulate estrogen signaling in vivo. The results suggest intriguing possibilities for the modulation of the risk of estrogen-dependent diseases by dietary means.

AB - Dietary phytoestrogens, such as the lignan metabolite enterolactone (ENL) and the isoflavone genistein (GEN), are suggested to modulate the risk of estrogen-dependent disease (e.g., breast cancer) through regulation of estrogen signaling. However, the effects of complex food items containing lignans or isoflavones on estrogen receptor (ER) transactivation have not been assessed so far. In this study, the modulation of ER-mediated signaling by dietary sources of lignans (cereals and flaxseed) and isoflavones (soy) was studied in vivo. Adult ovariectomized 3 x ERE-luciferase (luc) reporter mice received isocaloric diets supplemented with flaxseed, rye, wheat, or soy for 40 h or two weeks, and an additional group of mice was challenged with 17beta-estradiol (E(2)) following the two-week dietary intervention. In non-E(2)-treated mice, soy diet induced luc expression in liver, mammary gland, and pituitary gland while the other diets had no effects. Interestingly, all diets modulated the E(2)-induced luc expression. In particular rye diet efficiently reduced E(2)-induced luc expression as well as uterine growth, the hallmark of estrogen action in vivo. It is concluded that dietary sources of lignans and isoflavones can modulate estrogen signaling in vivo. The results suggest intriguing possibilities for the modulation of the risk of estrogen-dependent diseases by dietary means.

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DO - 10.1002/mnfr.200800487

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ER -

Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice

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