Disrupted Sleep: From Molecules to Cognition

TY - JOUR

T1 - Disrupted Sleep

T2 - From Molecules to Cognition

AU - Van Someren, Eus J W

AU - Cirelli, Chiara

AU - Dijk, Derk-Jan

AU - Van Cauter, Eve

AU - Schwartz, Sophie

AU - Chee, Michael W L

N1 - Copyright © 2015 the authors 0270-6474/15/3513889-07$15.00/0.

PY - 2015/10/14

Y1 - 2015/10/14

N2 - UNLABELLED: Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and experimental studies of these different forms of sleep disruption show deranged physiology from subcellular levels to complex affective behavior. In keeping with the multifaceted influence of sleep on health and well-being, we illustrate how the duration of sleep, its timing, and continuity can affect cellular ultrastructure, gene expression, metabolic and hormone regulation, mood, and vigilance. Recent brain imaging studies provide some clues on mechanisms underlying the most common cause of disrupted sleep (insomnia). These insights should ultimately result in adequate interventions to prevent and treat sleep disruption because of their high relevance to our most prevalent health problems.SIGNIFICANCE STATEMENT: Disruption of the duration, timing, and continuity of sleep affects cellular ultrastructure, gene expression, appetite regulation, hormone production, vigilance, and reward functions.

AB - UNLABELLED: Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and experimental studies of these different forms of sleep disruption show deranged physiology from subcellular levels to complex affective behavior. In keeping with the multifaceted influence of sleep on health and well-being, we illustrate how the duration of sleep, its timing, and continuity can affect cellular ultrastructure, gene expression, metabolic and hormone regulation, mood, and vigilance. Recent brain imaging studies provide some clues on mechanisms underlying the most common cause of disrupted sleep (insomnia). These insights should ultimately result in adequate interventions to prevent and treat sleep disruption because of their high relevance to our most prevalent health problems.SIGNIFICANCE STATEMENT: Disruption of the duration, timing, and continuity of sleep affects cellular ultrastructure, gene expression, appetite regulation, hormone production, vigilance, and reward functions.

U2 - 10.1523/JNEUROSCI.2592-15.2015

DO - 10.1523/JNEUROSCI.2592-15.2015

M3 - Article

C2 - 26468189

SN - 0270-6474

VL - 35

SP - 13889

EP - 13895

JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 41

ER -