Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Benjamin Egenlauf; Maren Schuhmann; Thomas Giese; Thomas Junghanss; Marija Stojkovic; Kathrin Tintelnot; Sybren de Hoog; Johann Greil; Elvira Richter; Maria Vehresschild; Claus Peter Heussel; Felix J F Herth; Michael Kreuter

doi:10.1159/000493429

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Benjamin Egenlauf, Maren Schuhmann, Thomas Giese, Thomas Junghanss, Marija Stojkovic, Kathrin Tintelnot, Sybren de Hoog, Johann Greil, Elvira Richter, Maria Vehresschild, Claus Peter Heussel, Felix J F Herth, Michael Kreuter

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GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

Originele taal-2	Engels
Pagina's (van-tot)	472-475
Aantal pagina's	4
Tijdschrift	Respiration; international review of thoracic diseases
Volume	97
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1159/000493429
Status	Gepubliceerd - mei 2019

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10.1159/000493429

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Egenlauf, B., Schuhmann, M., Giese, T., Junghanss, T., Stojkovic, M., Tintelnot, K., de Hoog, S., Greil, J., Richter, E., Vehresschild, M., Heussel, C. P., Herth, F. J. F., & Kreuter, M. (2019). Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency. Respiration; international review of thoracic diseases, 97(5), 472-475. https://doi.org/10.1159/000493429

@article{2a525aa397774bbbb4a2f3626311b1c1,

title = "Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency",

abstract = "GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.",

author = "Benjamin Egenlauf and Maren Schuhmann and Thomas Giese and Thomas Junghanss and Marija Stojkovic and Kathrin Tintelnot and {de Hoog}, Sybren and Johann Greil and Elvira Richter and Maria Vehresschild and Heussel, {Claus Peter} and Herth, {Felix J F} and Michael Kreuter",

note = "{\textcopyright} 2019 S. Karger AG, Basel.",

year = "2019",

month = may,

doi = "10.1159/000493429",

language = "English",

volume = "97",

pages = "472--475",

journal = "Respiration; international review of thoracic diseases",

issn = "0025-7931",

publisher = "S. Karger AG",

number = "5",

}

Egenlauf, B, Schuhmann, M, Giese, T, Junghanss, T, Stojkovic, M, Tintelnot, K, de Hoog, S, Greil, J, Richter, E, Vehresschild, M, Heussel, CP, Herth, FJF & Kreuter, M 2019, 'Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency', Respiration; international review of thoracic diseases, vol. 97, nr. 5, blz. 472-475. https://doi.org/10.1159/000493429

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency. / Egenlauf, Benjamin; Schuhmann, Maren; Giese, Thomas et al.
In: Respiration; international review of thoracic diseases, Vol. 97, Nr. 5, 05.2019, blz. 472-475.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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T1 - Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

AU - Egenlauf, Benjamin

AU - Schuhmann, Maren

AU - Giese, Thomas

AU - Junghanss, Thomas

AU - Stojkovic, Marija

AU - Tintelnot, Kathrin

AU - de Hoog, Sybren

AU - Greil, Johann

AU - Richter, Elvira

AU - Vehresschild, Maria

AU - Heussel, Claus Peter

AU - Herth, Felix J F

AU - Kreuter, Michael

PY - 2019/5

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N2 - GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

AB - GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

U2 - 10.1159/000493429

DO - 10.1159/000493429

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JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

IS - 5

ER -

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

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