DNA methylation differences in cortical grey and white matter in schizophrenia

Amber Berdenis van Berlekom, Nina Notman, Marjolein Am Sneeboer, Gijsje Jlj Snijders, Lotte C Houtepen, Danny M Nispeling, Yujie He, , Stella Dracheva, Elly M Hol, René S Kahn, Lot D de Witte, Marco P Boks

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

Originele taal-2Engels
Pagina's (van-tot)1157-1169
TijdschriftEpigenomics
Volume13
DOI's
StatusGepubliceerd - jul 2021

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