DNA methylation differences in cortical grey and white matter in schizophrenia

Amber Berdenis van Berlekom; Nina Notman; Marjolein Am Sneeboer; Gijsje Jlj Snijders; Lotte C Houtepen; Danny M Nispeling; Yujie He; Stella Dracheva; Elly M Hol; René S Kahn; Lot D de Witte; Marco P Boks

doi:10.2217/epi-2021-0077

DNA methylation differences in cortical grey and white matter in schizophrenia

Amber Berdenis van Berlekom, Nina Notman, Marjolein Am Sneeboer, Gijsje Jlj Snijders, Lotte C Houtepen, Danny M Nispeling, Yujie He, , Stella Dracheva, Elly M Hol, René S Kahn, Lot D de Witte, Marco P Boks

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Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

Originele taal-2	Engels
Pagina's (van-tot)	1157-1169
Tijdschrift	Epigenomics
Volume	13
DOI's	https://doi.org/10.2217/epi-2021-0077
Status	Gepubliceerd - jul. 2021

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@article{c7b81b89972644bcb1c644f325deb5b4,

title = "DNA methylation differences in cortical grey and white matter in schizophrenia",

abstract = "Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.",

author = "{van Berlekom}, {Amber Berdenis} and Nina Notman and Sneeboer, {Marjolein Am} and Snijders, {Gijsje Jlj} and Houtepen, {Lotte C} and Nispeling, {Danny M} and Yujie He and Stella Dracheva and Hol, {Elly M} and Kahn, {Ren{\'e} S} and {de Witte}, {Lot D} and Boks, {Marco P}",

year = "2021",

month = jul,

doi = "10.2217/epi-2021-0077",

language = "English",

volume = "13",

pages = "1157--1169",

journal = "Epigenomics",

issn = "1750-192X",

publisher = "Future Medicine Ltd.",

}

TY - JOUR

T1 - DNA methylation differences in cortical grey and white matter in schizophrenia

AU - van Berlekom, Amber Berdenis

AU - Notman, Nina

AU - Sneeboer, Marjolein Am

AU - Snijders, Gijsje Jlj

AU - Houtepen, Lotte C

AU - Nispeling, Danny M

AU - He, Yujie

AU - Dracheva, Stella

AU - Hol, Elly M

AU - Kahn, René S

AU - de Witte, Lot D

AU - Boks, Marco P

PY - 2021/7

Y1 - 2021/7

N2 - Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

AB - Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

U2 - 10.2217/epi-2021-0077

DO - 10.2217/epi-2021-0077

M3 - Article

C2 - 34323598

SN - 1750-192X

VL - 13

SP - 1157

EP - 1169

JO - Epigenomics

JF - Epigenomics

ER -

DNA methylation differences in cortical grey and white matter in schizophrenia

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