Ecology and genomics of Actinobacteria: new concepts for natural product discovery

Doris A. van Bergeijk; Barbara R. Terlouw; Marnix H. Medema; Gilles P. van Wezel

doi:10.1038/s41579-020-0379-y

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

Doris A. van Bergeijk, Barbara R. Terlouw, Marnix H. Medema (Co-auteur), Gilles P. van Wezel (Co-auteur)

NIOO - Microbial Ecology (ME)

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic versatility. They produce most of the clinically used antibiotics and a plethora of other natural products with medical or agricultural applications. Modern ‘omics’-based technologies have revealed that the genomic potential of Actinobacteria greatly outmatches the known chemical space. In this Review, we argue that combining insights into actinobacterial ecology with state-of-the-art computational approaches holds great promise to unlock this unexplored reservoir of actinobacterial metabolism. This enables the identification of small molecules and other stimuli that elicit the induction of poorly expressed biosynthetic gene clusters, which should help reinvigorate screening efforts for their precious bioactive natural products.

Originele taal-2	Engels
Pagina's (van-tot)	546-558
Aantal pagina's	13
Tijdschrift	Nature Reviews Microbiology
Volume	18
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1038/s41579-020-0379-y
Status	Gepubliceerd - 2020

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Ecology and genomics of Actinobacteria: new concepts for natural product discovery. / van Bergeijk, Doris A.; Terlouw, Barbara R.; Medema, Marnix H. (Co-auteur); van Wezel, Gilles P. (Co-auteur).

In: Nature Reviews Microbiology, Vol. 18, Nr. 10, 2020, blz. 546-558.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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AB - Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic versatility. They produce most of the clinically used antibiotics and a plethora of other natural products with medical or agricultural applications. Modern ‘omics’-based technologies have revealed that the genomic potential of Actinobacteria greatly outmatches the known chemical space. In this Review, we argue that combining insights into actinobacterial ecology with state-of-the-art computational approaches holds great promise to unlock this unexplored reservoir of actinobacterial metabolism. This enables the identification of small molecules and other stimuli that elicit the induction of poorly expressed biosynthetic gene clusters, which should help reinvigorate screening efforts for their precious bioactive natural products.

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Ecology and genomics of Actinobacteria: new concepts for natural product discovery

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