EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis

Wenrui Zhao; Eus J W Van Someren; Chenyu Li; Xinyuan Chen; Wenjun Gui; Yu Tian; Yunrui Liu; Xu Lei

doi:10.1016/j.smrv.2021.101457

EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis

Wenrui Zhao, Eus J W Van Someren, Chenyu Li, Xinyuan Chen, Wenjun Gui, Yu Tian, Yunrui Liu, Xu Lei

NIN

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

Samenvatting

Insomnia disorder (ID) has become the second-most common mental disorder. Despite burgeoning evidence for increased high-frequency electroencephalography (EEG) activity and cortical hyperarousal in ID, the detailed spectral features of this disorder during wakefulness and different sleep stages remain unclear. Therefore, we adopted a meta-analytic approach to systematically assess existing evidence on EEG spectral features in ID. Hedges's g was calculated by 148 effect sizes from 24 studies involving 977 participants. Our results demonstrate that, throughout wakefulness and sleep, patients with ID exhibited increased beta band power, although such increases sometimes extended into neighboring frequency bands. Patients with ID also exhibited increased theta and gamma power during wakefulness, as well as increased alpha and sigma power during rapid eye movement (REM) sleep. In addition, ID was associated with decreased delta power and increased theta, alpha, and sigma power during NREM sleep. The EEG measures of absolute and relative power have similar sensitivity in detecting spectral features of ID during wakefulness and REM sleep; however, relative power appeared to be a more sensitive biomarker during NREM sleep. Our study is the first statistics-based review to quantify EEG power spectra across stages of sleep and wakefulness in patients with ID.

Originele taal-2	Engels
Pagina's (van-tot)	101457
Tijdschrift	Sleep Medicine Reviews
Volume	59
DOI's	https://doi.org/10.1016/j.smrv.2021.101457
Status	Gepubliceerd - jan 2021

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10.1016/j.smrv.2021.101457

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title = "EEG spectral analysis in insomnia disorder: A systematic review and meta-analysis",

abstract = "Insomnia disorder (ID) has become the second-most common mental disorder. Despite burgeoning evidence for increased high-frequency electroencephalography (EEG) activity and cortical hyperarousal in ID, the detailed spectral features of this disorder during wakefulness and different sleep stages remain unclear. Therefore, we adopted a meta-analytic approach to systematically assess existing evidence on EEG spectral features in ID. Hedges's g was calculated by 148 effect sizes from 24 studies involving 977 participants. Our results demonstrate that, throughout wakefulness and sleep, patients with ID exhibited increased beta band power, although such increases sometimes extended into neighboring frequency bands. Patients with ID also exhibited increased theta and gamma power during wakefulness, as well as increased alpha and sigma power during rapid eye movement (REM) sleep. In addition, ID was associated with decreased delta power and increased theta, alpha, and sigma power during NREM sleep. The EEG measures of absolute and relative power have similar sensitivity in detecting spectral features of ID during wakefulness and REM sleep; however, relative power appeared to be a more sensitive biomarker during NREM sleep. Our study is the first statistics-based review to quantify EEG power spectra across stages of sleep and wakefulness in patients with ID.",

author = "Wenrui Zhao and {Van Someren}, {Eus J W} and Chenyu Li and Xinyuan Chen and Wenjun Gui and Yu Tian and Yunrui Liu and Xu Lei",

year = "2021",

month = jan,

doi = "10.1016/j.smrv.2021.101457",

language = "English",

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journal = "Sleep Medicine Reviews",

issn = "1087-0792",

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EEG spectral analysis in insomnia disorder : A systematic review and meta-analysis. / Zhao, Wenrui; Van Someren, Eus J W; Li, Chenyu; Chen, Xinyuan; Gui, Wenjun; Tian, Yu; Liu, Yunrui; Lei, Xu.

In: Sleep Medicine Reviews, Vol. 59, 01.2021, blz. 101457.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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T2 - A systematic review and meta-analysis

AU - Zhao, Wenrui

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AU - Li, Chenyu

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AU - Gui, Wenjun

AU - Tian, Yu

AU - Liu, Yunrui

AU - Lei, Xu

PY - 2021/1

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