In this paper, we develop a dynamic model for migratory interaction of regional systems that is based on an entropy operator. Next, we study the properties of this operator and establish the existence of a unique singular point in the dynamic entropy model. Here, we use monotonicity property of entropy operator on corresponding vector interval. We study Lyapunov stability of a dynamic system with entropy operator. Stability conditions have been obtained in terms of eigenvalues of linearized system’s matrix. Finally, we give an illustrative example for migratory interaction of regional systems.