Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

TY - JOUR

T1 - Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

AU - Brembeck, F.H.

AU - Schwarz-Romond, T.

AU - Bakkers, J.

AU - Wilhelm, S.

AU - Hammerschmidt, M.

AU - Birchmeier, W.

N1 - Reporting year: 2004

PY - 2004

Y1 - 2004

N2 - beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

AB - beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

U2 - 10.1101/gad.317604

DO - 10.1101/gad.317604

M3 - Article

SN - 0890-9369

VL - 18

SP - 2225

EP - 2230

JO - Genes & Development

JF - Genes & Development

IS - 18

ER -