Evolution of microRNA diversity and regulation in animals

TY - JOUR

T1 - Evolution of microRNA diversity and regulation in animals

AU - Berezikov, E.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic expansion in bilaterian animals and their function in providing robustness to transcriptional programmes suggest that miRNAs are instrumental in the evolution of organismal complexity. Advances in understanding miRNA biology, combined with the increasing availability of diverse sequenced genomes, have begun to reveal the molecular mechanisms that underlie the evolution of miRNAs and their targets. Insights are also emerging into how the evolution of miRNA-containing regulatory networks has contributed to organismal complexity.

AB - In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic expansion in bilaterian animals and their function in providing robustness to transcriptional programmes suggest that miRNAs are instrumental in the evolution of organismal complexity. Advances in understanding miRNA biology, combined with the increasing availability of diverse sequenced genomes, have begun to reveal the molecular mechanisms that underlie the evolution of miRNAs and their targets. Insights are also emerging into how the evolution of miRNA-containing regulatory networks has contributed to organismal complexity.

U2 - 10.1038/nrg3079

DO - 10.1038/nrg3079

M3 - Article

SN - 1471-0056

VL - 12

SP - 846

EP - 860

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 12

ER -