First report of neonatal sepsis due to Moesziomyces bullatus in a preterm low‐birth‐weight infant

Ojogba Mark Okolo; Anne D. Van Diepeningen; Bose Toma; Nnaemeka Emmanuel Nnadi; Mebi Grace Ayanbimpe; Ikenna Kenneth Onyedibe; Mohammed Zaino Sabitu; Benle Edmund Banwat; Marizeth Groenewald; Fabio Scordino; Zanyul Daniel Egah; Giuseppe Criseo; Orazio Romeo

doi:10.1099/jmmcr.0.000011

First report of neonatal sepsis due to Moesziomyces bullatus in a preterm low‐birth‐weight infant

Ojogba Mark Okolo, Anne D. Van Diepeningen, Bose Toma, Nnaemeka Emmanuel Nnadi, Mebi Grace Ayanbimpe, Ikenna Kenneth Onyedibe, Mohammed Zaino Sabitu, Benle Edmund Banwat, Marizeth Groenewald, Fabio Scordino, Zanyul Daniel Egah, Giuseppe Criseo, Orazio Romeo

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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Introduction: Moesziomyces spp. are connected with poaceous plants (Grass family), and Moesziomyces bullatus is commonly associated with smut in pearl millet. Currently, the scientific knowledge of this pathogen is limited to only a few taxonomic studies and there are no clinical reports that describe the isolation of M. bullatus from humans.
Case presentation: A female neonate born prematurely at 32 weeks of gestation was referred to the University Teaching Hospital in Jos, Nigeria, with a provisional diagnosis of preterm low birth weight at risk for sepsis. The birth weight of the newborn was 2000 g and her body temperature on admission was 34.3 °C. Blood cultures revealed the presence of a fungal isolate that was identified as M. bullatus by molecular methods. This fungus showed high MIC values for anidulafungin, caspofungin and micafungin, as well as fluconazole and 5‐flucytosine, and exhibited varying degrees of susceptibility to itraconazole, amphotericin B, posaconazole and voriconazole. To the best of our knowledge, this is the first case of a human M. bullatus bloodstream infection.
Conclusion: Here, we report the first case of an unusual human infection caused by the fungal plant pathogen M. bullatus and highlight a high level of resistance to classical and modern antifungal drugs.

Originele taal-2	Engels
Artikelnummer	10.1099/jmmcr.0.000011
Aantal pagina's	4
Tijdschrift	JMM Case Reports
Volume	2
DOI's	https://doi.org/10.1099/jmmcr.0.000011
Status	Gepubliceerd - 2015

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10.1099/jmmcr.0.000011

http://jmmcr.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.000011

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Okolo, O. M., Van Diepeningen, A. D., Toma, B., Nnadi, N. E., Ayanbimpe, M. G., Onyedibe, I. K., Sabitu, M. Z., Banwat, B. E., Groenewald, M., Scordino, F., Egah, Z. D., Criseo, G., & Romeo, O. (2015). First report of neonatal sepsis due to Moesziomyces bullatus in a preterm low‐birth‐weight infant. JMM Case Reports, 2, Artikel 10.1099/jmmcr.0.000011. https://doi.org/10.1099/jmmcr.0.000011

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title = "First report of neonatal sepsis due to Moesziomyces bullatus in a preterm low‐birth‐weight infant",

abstract = "Introduction: Moesziomyces spp. are connected with poaceous plants (Grass family), and Moesziomyces bullatus is commonly associated with smut in pearl millet. Currently, the scientific knowledge of this pathogen is limited to only a few taxonomic studies and there are no clinical reports that describe the isolation of M. bullatus from humans.Case presentation: A female neonate born prematurely at 32 weeks of gestation was referred to the University Teaching Hospital in Jos, Nigeria, with a provisional diagnosis of preterm low birth weight at risk for sepsis. The birth weight of the newborn was 2000 g and her body temperature on admission was 34.3 °C. Blood cultures revealed the presence of a fungal isolate that was identified as M. bullatus by molecular methods. This fungus showed high MIC values for anidulafungin, caspofungin and micafungin, as well as fluconazole and 5‐flucytosine, and exhibited varying degrees of susceptibility to itraconazole, amphotericin B, posaconazole and voriconazole. To the best of our knowledge, this is the first case of a human M. bullatus bloodstream infection.Conclusion: Here, we report the first case of an unusual human infection caused by the fungal plant pathogen M. bullatus and highlight a high level of resistance to classical and modern antifungal drugs.",

keywords = "antifungals, fungal sepsis, Moesziomyces bullatus, Pseudozyma, rare yeast infection, smut fungi",

author = "Okolo, {Ojogba Mark} and {Van Diepeningen}, {Anne D.} and Bose Toma and Nnadi, {Nnaemeka Emmanuel} and Ayanbimpe, {Mebi Grace} and Onyedibe, {Ikenna Kenneth} and Sabitu, {Mohammed Zaino} and Banwat, {Benle Edmund} and Marizeth Groenewald and Fabio Scordino and Egah, {Zanyul Daniel} and Giuseppe Criseo and Orazio Romeo",

year = "2015",

doi = "10.1099/jmmcr.0.000011",

language = "English",

volume = "2",

journal = "JMM Case Reports",

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AU - Okolo, Ojogba Mark

AU - Van Diepeningen, Anne D.

AU - Toma, Bose

AU - Nnadi, Nnaemeka Emmanuel

AU - Ayanbimpe, Mebi Grace

AU - Onyedibe, Ikenna Kenneth

AU - Sabitu, Mohammed Zaino

AU - Banwat, Benle Edmund

AU - Groenewald, Marizeth

AU - Scordino, Fabio

AU - Egah, Zanyul Daniel

AU - Criseo, Giuseppe

AU - Romeo, Orazio

PY - 2015

Y1 - 2015

N2 - Introduction: Moesziomyces spp. are connected with poaceous plants (Grass family), and Moesziomyces bullatus is commonly associated with smut in pearl millet. Currently, the scientific knowledge of this pathogen is limited to only a few taxonomic studies and there are no clinical reports that describe the isolation of M. bullatus from humans.Case presentation: A female neonate born prematurely at 32 weeks of gestation was referred to the University Teaching Hospital in Jos, Nigeria, with a provisional diagnosis of preterm low birth weight at risk for sepsis. The birth weight of the newborn was 2000 g and her body temperature on admission was 34.3 °C. Blood cultures revealed the presence of a fungal isolate that was identified as M. bullatus by molecular methods. This fungus showed high MIC values for anidulafungin, caspofungin and micafungin, as well as fluconazole and 5‐flucytosine, and exhibited varying degrees of susceptibility to itraconazole, amphotericin B, posaconazole and voriconazole. To the best of our knowledge, this is the first case of a human M. bullatus bloodstream infection.Conclusion: Here, we report the first case of an unusual human infection caused by the fungal plant pathogen M. bullatus and highlight a high level of resistance to classical and modern antifungal drugs.

AB - Introduction: Moesziomyces spp. are connected with poaceous plants (Grass family), and Moesziomyces bullatus is commonly associated with smut in pearl millet. Currently, the scientific knowledge of this pathogen is limited to only a few taxonomic studies and there are no clinical reports that describe the isolation of M. bullatus from humans.Case presentation: A female neonate born prematurely at 32 weeks of gestation was referred to the University Teaching Hospital in Jos, Nigeria, with a provisional diagnosis of preterm low birth weight at risk for sepsis. The birth weight of the newborn was 2000 g and her body temperature on admission was 34.3 °C. Blood cultures revealed the presence of a fungal isolate that was identified as M. bullatus by molecular methods. This fungus showed high MIC values for anidulafungin, caspofungin and micafungin, as well as fluconazole and 5‐flucytosine, and exhibited varying degrees of susceptibility to itraconazole, amphotericin B, posaconazole and voriconazole. To the best of our knowledge, this is the first case of a human M. bullatus bloodstream infection.Conclusion: Here, we report the first case of an unusual human infection caused by the fungal plant pathogen M. bullatus and highlight a high level of resistance to classical and modern antifungal drugs.

KW - antifungals

KW - fungal sepsis

KW - Moesziomyces bullatus

KW - Pseudozyma

KW - rare yeast infection

KW - smut fungi

U2 - 10.1099/jmmcr.0.000011

DO - 10.1099/jmmcr.0.000011

M3 - Article

SN - 2053-3721

VL - 2

JO - JMM Case Reports

JF - JMM Case Reports

M1 - 10.1099/jmmcr.0.000011

ER -

First report of neonatal sepsis due to Moesziomyces bullatus in a preterm low‐birth‐weight infant

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