fMRI protocol optimization for simultaneously studying small subcortical and cortical areas at 7 T

TY - JOUR

T1 - fMRI protocol optimization for simultaneously studying small subcortical and cortical areas at 7 T

AU - Miletić, S

AU - Bazin, P-L

AU - Weiskopf, N

AU - Van der Zwaag, W

AU - Forstmann, B U

AU - Trampel, R

N1 - Copyright © 2020. Published by Elsevier Inc.

PY - 2020/5/29

Y1 - 2020/5/29

N2 - Most fundamental cognitive processes rely on brain networks that include both cortical and subcortical structures. Studying such networks using functional magnetic resonance imaging (fMRI) requires a data acquisition protocol that provides blood-oxygenation-level dependent (BOLD) sensitivity across the entire brain. However, when using standard single echo, echo planar imaging protocols, researchers face a tradeoff between BOLD-sensitivity in cortex and in subcortical areas. Multi echo protocols avoid this tradeoff and can be used to optimize BOLD-sensitivity across the entire brain, at the cost of an increased repetition time. Here, we empirically compare the BOLD-sensitivity of a single echo protocol to a multi echo protocol. Both protocols were designed to meet the specific requirements for studying small, iron rich subcortical structures (including a relatively high spatial resolution and short echo times), while retaining coverage and BOLD-sensitivity in cortical areas. The results indicate that both sequences lead to similar BOLD-sensitivity across the brain at 7 T.

AB - Most fundamental cognitive processes rely on brain networks that include both cortical and subcortical structures. Studying such networks using functional magnetic resonance imaging (fMRI) requires a data acquisition protocol that provides blood-oxygenation-level dependent (BOLD) sensitivity across the entire brain. However, when using standard single echo, echo planar imaging protocols, researchers face a tradeoff between BOLD-sensitivity in cortex and in subcortical areas. Multi echo protocols avoid this tradeoff and can be used to optimize BOLD-sensitivity across the entire brain, at the cost of an increased repetition time. Here, we empirically compare the BOLD-sensitivity of a single echo protocol to a multi echo protocol. Both protocols were designed to meet the specific requirements for studying small, iron rich subcortical structures (including a relatively high spatial resolution and short echo times), while retaining coverage and BOLD-sensitivity in cortical areas. The results indicate that both sequences lead to similar BOLD-sensitivity across the brain at 7 T.

U2 - 10.1016/j.neuroimage.2020.116992

DO - 10.1016/j.neuroimage.2020.116992

M3 - Article

C2 - 32480037

SN - 1053-8119

VL - 219

SP - 116992

JO - NeuroImage

JF - NeuroImage

ER -