fMRI protocol optimization for simultaneously studying small subcortical and cortical areas at 7 T

S Miletić, P-L Bazin, N Weiskopf, W Van der Zwaag, B U Forstmann, R Trampel

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

19 Citaten (Scopus)
104 Downloads (Pure)

Samenvatting

Most fundamental cognitive processes rely on brain networks that include both cortical and subcortical structures. Studying such networks using functional magnetic resonance imaging (fMRI) requires a data acquisition protocol that provides blood-oxygenation-level dependent (BOLD) sensitivity across the entire brain. However, when using standard single echo, echo planar imaging protocols, researchers face a tradeoff between BOLD-sensitivity in cortex and in subcortical areas. Multi echo protocols avoid this tradeoff and can be used to optimize BOLD-sensitivity across the entire brain, at the cost of an increased repetition time. Here, we empirically compare the BOLD-sensitivity of a single echo protocol to a multi echo protocol. Both protocols were designed to meet the specific requirements for studying small, iron rich subcortical structures (including a relatively high spatial resolution and short echo times), while retaining coverage and BOLD-sensitivity in cortical areas. The results indicate that both sequences lead to similar BOLD-sensitivity across the brain at 7 T.

Originele taal-2Engels
Pagina's (van-tot)116992
TijdschriftNeuroImage
Volume219
DOI's
StatusGepubliceerd - 29 mei 2020

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