Four-dimensional computational ultrasound imaging of brain hemodynamics

TY - JOUR

T1 - Four-dimensional computational ultrasound imaging of brain hemodynamics

AU - Brown, Michael D

AU - Generowicz, Bastian S

AU - Dijkhuizen, Stephanie

AU - Koekkoek, Sebastiaan K E

AU - Strydis, Christos

AU - Bosch, Johannes G

AU - Arvanitis, Petros

AU - Springeling, Geert

AU - Leus, Geert J T

AU - De Zeeuw, Chris I

AU - Kruizinga, Pieter

PY - 2024/1/19

Y1 - 2024/1/19

N2 - Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.

AB - Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.

U2 - 10.1126/sciadv.adk7957

DO - 10.1126/sciadv.adk7957

M3 - Article

C2 - 38232164

SN - 2375-2548

VL - 10

SP - eadk7957

JO - Science advances

JF - Science advances

IS - 3

ER -