FoxM1 is required for execution of the mitotic programme and chromosome stability.

J. Laoukili, M.R.H. Kooistra, A. Bras, J. Kauw, R.M. Kerkhoven, A. Morrison, J.C. Clevers, R.H. Medema

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.
Originele taal-2Engels
Pagina's (van-tot)126-136
TijdschriftNature Cell Biology
Volume7
StatusGepubliceerd - 2005

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