FoxM1 is required for execution of the mitotic programme and chromosome stability.

TY - JOUR

T1 - FoxM1 is required for execution of the mitotic programme and chromosome stability.

AU - Laoukili, J.

AU - Kooistra, M.R.H.

AU - Bras, A.

AU - Kauw, J.

AU - Kerkhoven, R.M.

AU - Morrison, A.

AU - Clevers, J.C.

AU - Medema, R.H.

N1 - doi: 10.1038/ncb1217

PY - 2005

Y1 - 2005

N2 - Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.

AB - Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.

M3 - Article

SN - 1465-7392

VL - 7

SP - 126

EP - 136

JO - Nature Cell Biology

JF - Nature Cell Biology

ER -