Function and Therapeutic Potential of Non-Coding RNAs in Cardiac Fibrosis

TY - JOUR

T1 - Function and Therapeutic Potential of Non-Coding RNAs in Cardiac Fibrosis

AU - Creemers, Esther E

AU - van Rooij, Eva

PY - 2016/1/8

Y1 - 2016/1/8

N2 - Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is the transformation of fibroblasts into myofibroblasts, which secrete large amounts of extracellular matrix proteins. While the function of protein-coding genes in myofibroblast activation and fibrosis has been a topic of investigation for a long time, it has become clear that non-coding RNAs also play key roles in cardiac fibrosis. This review discusses the involvement of microRNAs and lncRNAs in cardiac fibrosis and summarizes the issues related to translating these findings into real life therapies.

AB - Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is the transformation of fibroblasts into myofibroblasts, which secrete large amounts of extracellular matrix proteins. While the function of protein-coding genes in myofibroblast activation and fibrosis has been a topic of investigation for a long time, it has become clear that non-coding RNAs also play key roles in cardiac fibrosis. This review discusses the involvement of microRNAs and lncRNAs in cardiac fibrosis and summarizes the issues related to translating these findings into real life therapies.

U2 - 10.1161/CIRCRESAHA.115.305242

DO - 10.1161/CIRCRESAHA.115.305242

M3 - Article

C2 - 26538569

SN - 0009-7330

JO - Circulation Research

JF - Circulation Research

ER -