Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

V.L. Thijssen, R. Postel, R.J. Brandwijk, R.P. Dings, I. Nesmelova, S. Satijn, N. Verhofstad, Y. Nakabeppu, L.G. Baum, J. Bakkers, K.H. Mayo, F. Poirier, A.W. Griffioen

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We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
Originele taal-2Niet gedefinieerd
TitelProceedings of the National Academy of Sciences of the United States of America
Pagina's15975-15980
StatusGepubliceerd - 2006

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