Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

V.L. Thijssen; R. Postel; R.J. Brandwijk; R.P. Dings; I. Nesmelova; S. Satijn; N. Verhofstad; Y. Nakabeppu; L.G. Baum; J. Bakkers; K.H. Mayo; F. Poirier; A.W. Griffioen

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

V.L. Thijssen, R. Postel, R.J. Brandwijk, R.P. Dings, I. Nesmelova, S. Satijn, N. Verhofstad, Y. Nakabeppu, L.G. Baum, J. Bakkers, K.H. Mayo, F. Poirier, A.W. Griffioen

Hubrecht Institute

Onderzoeksoutput: Hoofdstuk in boek/boekdeel › Bijdrage aan conferentie proceedings › Wetenschappelijk

423 Citaten (Scopus)

Samenvatting

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

Originele taal-2	Niet gedefinieerd
Titel	Proceedings of the National Academy of Sciences of the United States of America
Pagina's	15975-15980
Status	Gepubliceerd - 2006

Citeer dit

Thijssen, V. L., Postel, R., Brandwijk, R. J., Dings, R. P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L. G., Bakkers, J., Mayo, K. H., Poirier, F., & Griffioen, A. W. (2006). Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. In Proceedings of the National Academy of Sciences of the United States of America (blz. 15975-15980)

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title = "Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.",

abstract = "We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.",

author = "V.L. Thijssen and R. Postel and R.J. Brandwijk and R.P. Dings and I. Nesmelova and S. Satijn and N. Verhofstad and Y. Nakabeppu and L.G. Baum and J. Bakkers and K.H. Mayo and F. Poirier and A.W. Griffioen",

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pages = "15975--15980",

booktitle = "Proceedings of the National Academy of Sciences of the United States of America",

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T1 - Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

AU - Thijssen, V.L.

AU - Postel, R.

AU - Brandwijk, R.J.

AU - Dings, R.P.

AU - Nesmelova, I.

AU - Satijn, S.

AU - Verhofstad, N.

AU - Nakabeppu, Y.

AU - Baum, L.G.

AU - Bakkers, J.

AU - Mayo, K.H.

AU - Poirier, F.

AU - Griffioen, A.W.

N1 - Reporting year: 2006

PY - 2006

Y1 - 2006

N2 - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

AB - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

M3 - Bijdrage aan conferentie proceedings

SP - 15975

EP - 15980

BT - Proceedings of the National Academy of Sciences of the United States of America

ER -