Gene expression: long-term gene silencing by RNAi.

N.L. Vastenhouw; K. Brunschwig; K.L. Okihara; F. Muller; M. Tijsterman; R.H.A. Plasterk

doi:10.1038/442882a

Gene expression: long-term gene silencing by RNAi.

N.L. Vastenhouw, K. Brunschwig, K.L. Okihara, F. Muller, M. Tijsterman, R.H.A. Plasterk

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

224 Citaten (Scopus)

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Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can induce transcriptional silencing effects that are inherited indefinitely in the absence of the original trigger. Our findings may prove useful in the ongoing development of RNAi to treat disease.

Originele taal-2	Engels
Tijdschrift	Nature
Volume	442
Nummer van het tijdschrift	7105
DOI's	https://doi.org/10.1038/442882a
Status	Gepubliceerd - 2006

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abstract = "Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can induce transcriptional silencing effects that are inherited indefinitely in the absence of the original trigger. Our findings may prove useful in the ongoing development of RNAi to treat disease.",

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AB - Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can induce transcriptional silencing effects that are inherited indefinitely in the absence of the original trigger. Our findings may prove useful in the ongoing development of RNAi to treat disease.

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Gene expression: long-term gene silencing by RNAi.

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