Genome-wide prediction and transcriptome analysis of sugar transporters in four ascomycete fungi

Li Xu, Jiajia Li, Victor M Gonzalez Ramos, Christina Lyra, Ad Wiebenga, Igor V Grigoriev, Ronald P de Vries, Miia R Mäkelä, Mao Peng

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

2 Citaten (Scopus)

Samenvatting

The import of plant-derived small sugars by sugar transporters (STs) has received increasing interest due to its important biological role and great industrial potential. STs are important targets of genetic engineering to improve fungal plant biomass conversion. Comparatively analysis of the genome-wide prevalence and transcriptomics of STs was performed in four filamentous fungi: Aspergillus niger, Aspergillus nidulans, Penicillium subrubescens and Trichoderma reesei. Using phylogenetic analysis and literature mining, their predicted STs were divided into ten subfamilies with putative sugar specificities assigned. In addition, transcriptome analysis revealed complex expression profiles among different STs subfamilies and fungal species, indicating a sophisticated transcriptome regulation and functional diversity of fungal STs. Several STs showed strong co-expression with other genes involved in sugar utilization, encoding CAZymes and sugar catabolic enzymes. This study provides new insights into the diversity of STs at the genomic/transcriptomic level, facilitating their biochemical characterization and metabolic engineering.

Originele taal-2Engels
Pagina's (van-tot)130006
TijdschriftBioresource Technology
Volume391
Nummer van het tijdschriftPt B
DOI's
StatusGepubliceerd - jan. 2024

Vingerafdruk

Duik in de onderzoeksthema's van 'Genome-wide prediction and transcriptome analysis of sugar transporters in four ascomycete fungi'. Samen vormen ze een unieke vingerafdruk.

Citeer dit