Genomic features and evolution of lifestyles support the recognition of distinct genera among fusarioid fungi

Bartosz Ulaszewski; Marcelo Sandoval-Denis; Johannes Z. Groenewald; Marileide M. Costa; Bagdevi Mishra; Sebastian Ploch; Pedro W. Crous; Marco Thines

doi:10.1007/s11557-024-02025-4

Genomic features and evolution of lifestyles support the recognition of distinct genera among fusarioid fungi

Bartosz Ulaszewski, Marcelo Sandoval-Denis, Johannes Z. Groenewald, Marileide M. Costa, Bagdevi Mishra, Sebastian Ploch, Pedro W. Crous, Marco Thines

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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The family Nectriaceae (Hypocreales, Sordariomycetes) includes saprobes, endophytes and numerous important pathogens, several of which are of high commercial interest. Presently there are numerous genera scattered throughout the Nectriaceae that have a fusarioid asexual morph (i.e., genera with fusarium-like macroconidia). Fusarioid fungi encompass diverse lifestyles, including plant, human, and animal pathogens or associates, saprobes, lichenicolous species, endophytes, and mycophilic taxa. The fusarioid genera in Nectriaceae do not only differ in their sexual morphs, but also in their asexual morphology and biology, although their ecology has remained rather unclear. While genome data are available for numerous species, this has been mostly focused on Fusarium sensu stricto, as the genus encompasses most of the economically important species in this generic complex. To compliment this, we expanded the sampling, and generated whole genome sequences for 40 isolates representing the genera Atractium, Bisifusarium, Cinnamomeonectria, Corinectria, Cosmospora, Cyanonectria, Cylindrodendrum, Dialonectria, Fusarium, Fusicolla, Geejayessia, Ilyonectria, Macroconia, Macronectria, Microcera, Neocosmospora, Neonectria, Pseudofusicolla, Rectifusarium, Rugonectria, Scolecofusarium, Thelonectria, and Tumenectria. Phylogenomic ancestral reconstructions showed that plant pathogenicity is most likely ancestral to Fusarium and cylindrocarpioid genera, and revealed multiple and frequent lifestyle transitions. Although many species are prolific generalists, several genera appear to be more specialised, being primarily plant pathogens, mycophilic, or insect associated, while endophytism or plant pathogenicity evolved several times, and more recently in Fusarium. The broadly sampled Nectriaceae genomes supported morphological differences between most genera of Nectriaceae, mirrored by genome sizes, lactic enzymes, biosynthetic gene clusters, and small secreted proteins. Furthermore, it also supported a narrow circumscription of Fusarium in Nectriaceae that equals its morphology (Gibberella sexual morphs), and biology.

Originele taal-2	Engels
Artikelnummer	20
Aantal pagina's	31
Tijdschrift	Mycological Progress
Volume	24
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1007/s11557-024-02025-4
Status	Gepubliceerd - feb. 2025

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10.1007/s11557-024-02025-4

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@article{cf08ab2f16af417c83180b97b7e1d160,

title = "Genomic features and evolution of lifestyles support the recognition of distinct genera among fusarioid fungi",

abstract = "The family Nectriaceae (Hypocreales, Sordariomycetes) includes saprobes, endophytes and numerous important pathogens, several of which are of high commercial interest. Presently there are numerous genera scattered throughout the Nectriaceae that have a fusarioid asexual morph (i.e., genera with fusarium-like macroconidia). Fusarioid fungi encompass diverse lifestyles, including plant, human, and animal pathogens or associates, saprobes, lichenicolous species, endophytes, and mycophilic taxa. The fusarioid genera in Nectriaceae do not only differ in their sexual morphs, but also in their asexual morphology and biology, although their ecology has remained rather unclear. While genome data are available for numerous species, this has been mostly focused on Fusarium sensu stricto, as the genus encompasses most of the economically important species in this generic complex. To compliment this, we expanded the sampling, and generated whole genome sequences for 40 isolates representing the genera Atractium, Bisifusarium, Cinnamomeonectria, Corinectria, Cosmospora, Cyanonectria, Cylindrodendrum, Dialonectria, Fusarium, Fusicolla, Geejayessia, Ilyonectria, Macroconia, Macronectria, Microcera, Neocosmospora, Neonectria, Pseudofusicolla, Rectifusarium, Rugonectria, Scolecofusarium, Thelonectria, and Tumenectria. Phylogenomic ancestral reconstructions showed that plant pathogenicity is most likely ancestral to Fusarium and cylindrocarpioid genera, and revealed multiple and frequent lifestyle transitions. Although many species are prolific generalists, several genera appear to be more specialised, being primarily plant pathogens, mycophilic, or insect associated, while endophytism or plant pathogenicity evolved several times, and more recently in Fusarium. The broadly sampled Nectriaceae genomes supported morphological differences between most genera of Nectriaceae, mirrored by genome sizes, lactic enzymes, biosynthetic gene clusters, and small secreted proteins. Furthermore, it also supported a narrow circumscription of Fusarium in Nectriaceae that equals its morphology (Gibberella sexual morphs), and biology.",

keywords = "Biosynthetic gene clusters, CAZymes, Comparative genomics, Endophytes, Fusarium, Lifestyle evolution, Plant pathogens, Saprobes, Small-secreted proteins",

author = "Bartosz Ulaszewski and Marcelo Sandoval-Denis and Groenewald, {Johannes Z.} and Costa, {Marileide M.} and Bagdevi Mishra and Sebastian Ploch and Crous, {Pedro W.} and Marco Thines",

year = "2025",

month = feb,

doi = "10.1007/s11557-024-02025-4",

language = "English",

volume = "24",

journal = "Mycological Progress",

issn = "1861-8952",

publisher = "Springer Verlag GmbH",

number = "1",

}

Genomic features and evolution of lifestyles support the recognition of distinct genera among fusarioid fungi. / Ulaszewski, Bartosz; Sandoval-Denis, Marcelo ; Groenewald, Johannes Z. et al.
In: Mycological Progress, Vol. 24, Nr. 1, 20, 02.2025.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

TY - JOUR

T1 - Genomic features and evolution of lifestyles support the recognition of distinct genera among fusarioid fungi

AU - Ulaszewski, Bartosz

AU - Sandoval-Denis, Marcelo

AU - Groenewald, Johannes Z.

AU - Costa, Marileide M.

AU - Mishra, Bagdevi

AU - Ploch, Sebastian

AU - Crous, Pedro W.

AU - Thines, Marco

PY - 2025/2

Y1 - 2025/2

N2 - The family Nectriaceae (Hypocreales, Sordariomycetes) includes saprobes, endophytes and numerous important pathogens, several of which are of high commercial interest. Presently there are numerous genera scattered throughout the Nectriaceae that have a fusarioid asexual morph (i.e., genera with fusarium-like macroconidia). Fusarioid fungi encompass diverse lifestyles, including plant, human, and animal pathogens or associates, saprobes, lichenicolous species, endophytes, and mycophilic taxa. The fusarioid genera in Nectriaceae do not only differ in their sexual morphs, but also in their asexual morphology and biology, although their ecology has remained rather unclear. While genome data are available for numerous species, this has been mostly focused on Fusarium sensu stricto, as the genus encompasses most of the economically important species in this generic complex. To compliment this, we expanded the sampling, and generated whole genome sequences for 40 isolates representing the genera Atractium, Bisifusarium, Cinnamomeonectria, Corinectria, Cosmospora, Cyanonectria, Cylindrodendrum, Dialonectria, Fusarium, Fusicolla, Geejayessia, Ilyonectria, Macroconia, Macronectria, Microcera, Neocosmospora, Neonectria, Pseudofusicolla, Rectifusarium, Rugonectria, Scolecofusarium, Thelonectria, and Tumenectria. Phylogenomic ancestral reconstructions showed that plant pathogenicity is most likely ancestral to Fusarium and cylindrocarpioid genera, and revealed multiple and frequent lifestyle transitions. Although many species are prolific generalists, several genera appear to be more specialised, being primarily plant pathogens, mycophilic, or insect associated, while endophytism or plant pathogenicity evolved several times, and more recently in Fusarium. The broadly sampled Nectriaceae genomes supported morphological differences between most genera of Nectriaceae, mirrored by genome sizes, lactic enzymes, biosynthetic gene clusters, and small secreted proteins. Furthermore, it also supported a narrow circumscription of Fusarium in Nectriaceae that equals its morphology (Gibberella sexual morphs), and biology.

AB - The family Nectriaceae (Hypocreales, Sordariomycetes) includes saprobes, endophytes and numerous important pathogens, several of which are of high commercial interest. Presently there are numerous genera scattered throughout the Nectriaceae that have a fusarioid asexual morph (i.e., genera with fusarium-like macroconidia). Fusarioid fungi encompass diverse lifestyles, including plant, human, and animal pathogens or associates, saprobes, lichenicolous species, endophytes, and mycophilic taxa. The fusarioid genera in Nectriaceae do not only differ in their sexual morphs, but also in their asexual morphology and biology, although their ecology has remained rather unclear. While genome data are available for numerous species, this has been mostly focused on Fusarium sensu stricto, as the genus encompasses most of the economically important species in this generic complex. To compliment this, we expanded the sampling, and generated whole genome sequences for 40 isolates representing the genera Atractium, Bisifusarium, Cinnamomeonectria, Corinectria, Cosmospora, Cyanonectria, Cylindrodendrum, Dialonectria, Fusarium, Fusicolla, Geejayessia, Ilyonectria, Macroconia, Macronectria, Microcera, Neocosmospora, Neonectria, Pseudofusicolla, Rectifusarium, Rugonectria, Scolecofusarium, Thelonectria, and Tumenectria. Phylogenomic ancestral reconstructions showed that plant pathogenicity is most likely ancestral to Fusarium and cylindrocarpioid genera, and revealed multiple and frequent lifestyle transitions. Although many species are prolific generalists, several genera appear to be more specialised, being primarily plant pathogens, mycophilic, or insect associated, while endophytism or plant pathogenicity evolved several times, and more recently in Fusarium. The broadly sampled Nectriaceae genomes supported morphological differences between most genera of Nectriaceae, mirrored by genome sizes, lactic enzymes, biosynthetic gene clusters, and small secreted proteins. Furthermore, it also supported a narrow circumscription of Fusarium in Nectriaceae that equals its morphology (Gibberella sexual morphs), and biology.

KW - Biosynthetic gene clusters

KW - CAZymes

KW - Comparative genomics

KW - Endophytes

KW - Fusarium

KW - Lifestyle evolution

KW - Plant pathogens

KW - Saprobes

KW - Small-secreted proteins

U2 - 10.1007/s11557-024-02025-4

DO - 10.1007/s11557-024-02025-4

M3 - Article

SN - 1861-8952

VL - 24

JO - Mycological Progress

JF - Mycological Progress

IS - 1

M1 - 20

ER -