Getting the genome in shape: the formation of loops, domains and compartments

TY - JOUR

T1 - Getting the genome in shape

T2 - the formation of loops, domains and compartments

AU - Bouwman, Britta Am

AU - de Laat, Wouter

PY - 2015

Y1 - 2015

N2 - The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

AB - The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

U2 - 10.1186/s13059-015-0730-1

DO - 10.1186/s13059-015-0730-1

M3 - Article

C2 - 26257189

SN - 1474-7596

VL - 16

SP - 154

JO - Genome Biology

JF - Genome Biology

ER -