Glial origin of mesenchymal stem cells in a tooth model system

Nina Kaukua, Maryam Khatibi Shahidi, Chrysoula Konstantinidou, Vyacheslav Dyachuk, Marketa Kaucka, Alessandro Furlan, Zhengwen An, Longlong Wang, Isabell Hultman, Lars Ahrlund-Richter, Hans Blom, Hjalmar Brismar, Natalia Assaife Lopes, Vassilis Pachnis, Ueli Suter, Hans Clevers, Irma Thesleff, Paul Sharpe, Patrik Ernfors, Kaj FriedIgor Adameyko

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Mesenchymal stem cells occupy niches in stromal tissues where they provide sources of cells for specialized mesenchymal derivatives during growth and repair. The origins of mesenchymal stem cells have been the subject of considerable discussion, and current consensus holds that perivascular cells form mesenchymal stem cells in most tissues. The continuously growing mouse incisor tooth offers an excellent model to address the origin of mesenchymal stem cells. These stem cells dwell in a niche at the tooth apex where they produce a variety of differentiated derivatives. Cells constituting the tooth are mostly derived from two embryonic sources: neural crest ectomesenchyme and ectodermal epithelium. It has been thought for decades that the dental mesenchymal stem cells giving rise to pulp cells and odontoblasts derive from neural crest cells after their migration in the early head and formation of ectomesenchymal tissue. Here we show that a significant population of mesenchymal stem cells during development, self-renewal and repair of a tooth are derived from peripheral nerve-associated glia. Glial cells generate multipotent mesenchymal stem cells that produce pulp cells and odontoblasts. By combining a clonal colour-coding technique with tracing of peripheral glia, we provide new insights into the dynamics of tooth organogenesis and growth.

Originele taal-2Engels
Pagina's (van-tot)551-4
Aantal pagina's4
TijdschriftNature
Volume513
Nummer van het tijdschrift7519
DOI's
StatusGepubliceerd - 25 sep 2014

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