Samenvatting
Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 318-322 |
Tijdschrift | Trends in Genetics |
Volume | 21 |
Nummer van het tijdschrift | 6 |
DOI's | |
Status | Gepubliceerd - 2005 |