Haplotype-based genetics in mice and rats

TY - JOUR

T1 - Haplotype-based genetics in mice and rats

AU - Cuppen, E.

N1 - Reporting year: 2005 Metis note: 15922828

PY - 2005

Y1 - 2005

N2 - Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.

AB - Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.

U2 - 10.1016/j.tig.2005.03.010

DO - 10.1016/j.tig.2005.03.010

M3 - Article

SN - 0168-9525

VL - 21

SP - 318

EP - 322

JO - Trends in Genetics

JF - Trends in Genetics

IS - 6

ER -