TY - JOUR
T1 - Heterogeneity in mRNA Translation
AU - Sonneveld, Stijn
AU - Verhagen, Bram M P
AU - Tanenbaum, Marvin E
N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression 'noise' remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.
AB - During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression 'noise' remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.
U2 - 10.1016/j.tcb.2020.04.008
DO - 10.1016/j.tcb.2020.04.008
M3 - Book/Film/Article review
C2 - 32461030
SN - 0962-8924
VL - 30
SP - 606
EP - 618
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -