Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

Francesca Mattiroli; Lorenza Penengo

doi:10.1016/j.tig.2020.12.005

Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Boek/film/artikelrecensie › Wetenschappelijk

132 Citaten (Scopus)

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Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.

Originele taal-2	Engels
Pagina's (van-tot)	566-581
Aantal pagina's	16
Tijdschrift	Trends in Genetics
Volume	37
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.tig.2020.12.005
Status	Gepubliceerd - jun. 2021

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title = "Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability",

abstract = "Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.",

keywords = "Animals, DNA Damage, DNA Repair, Genomic Instability, Histones/genetics, Humans, Methylation, Phosphorylation, Ubiquitin/genetics, Ubiquitination",

author = "Francesca Mattiroli and Lorenza Penengo",

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doi = "10.1016/j.tig.2020.12.005",

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AU - Penengo, Lorenza

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N2 - Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.

AB - Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.

KW - Animals

KW - DNA Damage

KW - DNA Repair

KW - Genomic Instability

KW - Histones/genetics

KW - Humans

KW - Methylation

KW - Phosphorylation

KW - Ubiquitin/genetics

KW - Ubiquitination

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DO - 10.1016/j.tig.2020.12.005

M3 - Book/Film/Article review

C2 - 33485674

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EP - 581

JO - Trends in Genetics

JF - Trends in Genetics

IS - 6

ER -

Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

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