Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

TY - JOUR

T1 - Histone Ubiquitination

T2 - An Integrative Signaling Platform in Genome Stability

AU - Mattiroli, Francesca

AU - Penengo, Lorenza

N1 - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.

AB - Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination regulates genome stability. Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway. We discuss players involved and potential implications of histone (phospho)ubiquitination on chromatin structure, and we highlight exciting open questions for future research.

KW - Animals

KW - DNA Damage

KW - DNA Repair

KW - Genomic Instability

KW - Histones/genetics

KW - Humans

KW - Methylation

KW - Phosphorylation

KW - Ubiquitin/genetics

KW - Ubiquitination

U2 - 10.1016/j.tig.2020.12.005

DO - 10.1016/j.tig.2020.12.005

M3 - Book/Film/Article review

C2 - 33485674

SN - 0168-9525

VL - 37

SP - 566

EP - 581

JO - Trends in Genetics

JF - Trends in Genetics

IS - 6

ER -