Hox genes and regional patterning of the vertebrate body plan

M. Mallo; D.M. Wellik; J. Deschamps

doi:10.1016/j.ydbio.2010.04.024

Hox genes and regional patterning of the vertebrate body plan

M. Mallo, D.M. Wellik, J. Deschamps

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

348 Citaten (Scopus)

Samenvatting

Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.

Originele taal-2	Engels
Pagina's (van-tot)	7-15
Tijdschrift	Developmental Biology
Volume	344
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.ydbio.2010.04.024
Status	Gepubliceerd - 2010

Toegang tot document

10.1016/j.ydbio.2010.04.024

Citeer dit

@article{a71a4f000fd84381a30d58cd1814bcb2,

title = "Hox genes and regional patterning of the vertebrate body plan",

abstract = "Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.",

author = "M. Mallo and D.M. Wellik and J. Deschamps",

note = "Reporting year: 2010",

year = "2010",

doi = "10.1016/j.ydbio.2010.04.024",

language = "English",

volume = "344",

pages = "7--15",

journal = "Developmental Biology",

issn = "0012-1606",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - Hox genes and regional patterning of the vertebrate body plan

AU - Mallo, M.

AU - Wellik, D.M.

AU - Deschamps, J.

N1 - Reporting year: 2010

PY - 2010

Y1 - 2010

N2 - Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.

AB - Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.

U2 - 10.1016/j.ydbio.2010.04.024

DO - 10.1016/j.ydbio.2010.04.024

M3 - Article

SN - 0012-1606

VL - 344

SP - 7

EP - 15

JO - Developmental Biology

JF - Developmental Biology

IS - 1

ER -

Hox genes and regional patterning of the vertebrate body plan

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit