Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: a proof-of-concept study

TY - JOUR

T1 - Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries

T2 - a proof-of-concept study

AU - Soloukey, S

AU - Collée, E

AU - Verhoef, L

AU - Satoer, D D

AU - Dirven, C M F

AU - Bos, E M

AU - Schouten, J W

AU - Generowicz, B S

AU - Mastik, F

AU - De Zeeuw, C I

AU - Koekkoek, S K E

AU - Vincent, A J P E

AU - Smits, M

AU - Kruizinga, P

N1 - Copyright © 2023. Published by Elsevier Inc.

PY - 2023/10/30

Y1 - 2023/10/30

N2 - Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond spatiotemporal resolution available in large fields-of-view. In this proof-of-concept study we show that: A) fUS reveals the same eloquent regions as found by fMRI while concomitantly visualizing in-vivo microvascular morphology underlying these functional hemodynamics and B) fUS-based functional maps are confirmed by Electrocortical Stimulation Mapping (ESM), the current gold-standard in awake neurosurgical practice. This unique cross-modality experiment was performed using motor, visual and language-related functional tasks in patients undergoing awake brain tumor resection. The current work serves as an important milestone towards further maturity of fUS as well as a novel avenue to increase our understanding of hemodynamics-based functional brain imaging.

AB - Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond spatiotemporal resolution available in large fields-of-view. In this proof-of-concept study we show that: A) fUS reveals the same eloquent regions as found by fMRI while concomitantly visualizing in-vivo microvascular morphology underlying these functional hemodynamics and B) fUS-based functional maps are confirmed by Electrocortical Stimulation Mapping (ESM), the current gold-standard in awake neurosurgical practice. This unique cross-modality experiment was performed using motor, visual and language-related functional tasks in patients undergoing awake brain tumor resection. The current work serves as an important milestone towards further maturity of fUS as well as a novel avenue to increase our understanding of hemodynamics-based functional brain imaging.

U2 - 10.1016/j.neuroimage.2023.120435

DO - 10.1016/j.neuroimage.2023.120435

M3 - Article

C2 - 37914090

SN - 1053-8119

VL - 283

SP - 120435

JO - NeuroImage

JF - NeuroImage

ER -