Human-Derived Model Systems in Gynecological Cancer Research

Kadi Lõhmussaar; Matteo Boretto; Hans Clevers

doi:10.1016/j.trecan.2020.07.007

Human-Derived Model Systems in Gynecological Cancer Research

Kadi Lõhmussaar, Matteo Boretto, Hans Clevers

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Boek/film/artikelrecensie › Wetenschappelijk

32 Citaten (Scopus)

Samenvatting

The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.

Originele taal-2	Engels
Pagina's (van-tot)	1031-1043
Aantal pagina's	13
Tijdschrift	Trends in Cancer
Volume	6
Nummer van het tijdschrift	12
DOI's	https://doi.org/10.1016/j.trecan.2020.07.007
Status	Gepubliceerd - dec. 2020

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title = "Human-Derived Model Systems in Gynecological Cancer Research",

abstract = "The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.",

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AU - Lõhmussaar, Kadi

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AB - The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.

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Human-Derived Model Systems in Gynecological Cancer Research

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