Identical cells with different 3D genomes; cause and consequences?

TY - JOUR

T1 - Identical cells with different 3D genomes; cause and consequences?

AU - Krijger, P.H.

AU - de Laat, W.

N1 - Reporting year: 2013

PY - 2013

Y1 - 2013

N2 - The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We propose a model (dog-on-a-lead model) to understand the principles behind and consequences of cell-specific remote DNA contacts and speculate that cell-specific genome topologies can cause variegated gene expression among otherwise identical cells.

AB - The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We propose a model (dog-on-a-lead model) to understand the principles behind and consequences of cell-specific remote DNA contacts and speculate that cell-specific genome topologies can cause variegated gene expression among otherwise identical cells.

U2 - 10.1016/j.gde.2012.12.010

DO - 10.1016/j.gde.2012.12.010

M3 - Article

SN - 0959-437X

VL - 23

SP - 191

EP - 196

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

IS - 2

ER -