Imaging hallmarks of cancer in living mice

TY - JOUR

T1 - Imaging hallmarks of cancer in living mice

AU - Ellenbroek, Saskia I J

AU - van Rheenen, Jacco

PY - 2014/6

Y1 - 2014/6

N2 - To comprehend the complexity of cancer, the biological characteristics acquired during the initiation and progression of tumours were classified as the 'hallmarks of cancer'. Intravital microscopy techniques have been developed to study individual cells that acquire these crucial traits, by visualizing tissues with cellular or subcellular resolution in living animals. In this Review, we highlight the latest intravital microscopy techniques that have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of various hallmarks of cancer. In addition, we discuss the application of intravital microscopy techniques to cancer therapy, as well as limitations and future perspectives for these techniques.

AB - To comprehend the complexity of cancer, the biological characteristics acquired during the initiation and progression of tumours were classified as the 'hallmarks of cancer'. Intravital microscopy techniques have been developed to study individual cells that acquire these crucial traits, by visualizing tissues with cellular or subcellular resolution in living animals. In this Review, we highlight the latest intravital microscopy techniques that have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of various hallmarks of cancer. In addition, we discuss the application of intravital microscopy techniques to cancer therapy, as well as limitations and future perspectives for these techniques.

KW - Animals

KW - Diagnostic Imaging

KW - Disease Progression

KW - Mice

KW - Neoplasms

U2 - 10.1038/nrc3742

DO - 10.1038/nrc3742

M3 - Article

C2 - 24854083

SN - 1474-175X

VL - 14

SP - 406

EP - 418

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 6

ER -