Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial

Jeanne Leerssen; Jessica C Foster-Dingley; Oti Lakbila-Kamal; Laura M S Dekkers; Anne C W Albers; Savannah L C Ikelaar; Teodora Maksimovic; Rick Wassing; Simon J Houtman; Tom Bresser; Tessa F Blanken; Bart Te Lindert; Jennifer R Ramautar; Eus J W Van Someren

doi:10.1186/s12888-020-02554-8

Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial

Jeanne Leerssen, Jessica C Foster-Dingley, Oti Lakbila-Kamal, Laura M S Dekkers, Anne C W Albers, Savannah L C Ikelaar, Teodora Maksimovic, Rick Wassing, Simon J Houtman, Tom Bresser, Tessa F Blanken, Bart Te Lindert, Jennifer R Ramautar, Eus J W Van Someren

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Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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BACKGROUND: Major depressive disorder is among the most burdening and costly chronic health hazards. Since its prognosis is poor and treatment effectiveness is moderate at best, prevention would be the strategy of first choice. Insomnia may be the best modifiable risk factor. Insomnia is highly prevalent (4-10%) and meta-analysis estimates ±13% of people with insomnia to develop depression within a year. Among people with insomnia, recent work identified three subtypes with a particularly high lifetime risk of depression. The current randomized controlled trial (RCT) evaluates the effects of internet-guided Cognitive Behavioral Therapy for Insomnia (CBT-I), Chronobiological Therapy (CT), and their combination on insomnia and the development of depressive symptoms.

METHODS: We aim to include 120 participants with Insomnia Disorder (ID) of one of the three subtypes that are more prone to develop depression. In a two by two factorial repeated measures design, participants will be randomized to CBT-I, CT, CBT-I + CT or treatment as usual, and followed up for one year. The primary outcome is the change, relative to baseline, of the severity of depressive symptoms integrated over four follow-ups spanning one year. Secondary outcome measures include a diagnosis of major depressive disorder, insomnia severity, sleep diaries, actigraphy, cost-effectiveness, and brain structure and function.

DISCUSSION: Pre-selection of three high-risk insomnia subtypes allows for a sensitive assessment of the possibility to prevent the development and worsening of depressive symptoms through interventions targeting insomnia.

TRIAL REGISTRATION: Netherlands Trial Register (NL7359). Registered on 19 October 2018.

Originele taal-2	Engels
Pagina's (van-tot)	163
Tijdschrift	BMC Psychiatry
Volume	20
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1186/s12888-020-02554-8
Status	Gepubliceerd - 2020

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10.1186/s12888-020-02554-8

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Leerssen, J., Foster-Dingley, J. C., Lakbila-Kamal, O., Dekkers, L. M. S., Albers, A. C. W., Ikelaar, S. L. C., Maksimovic, T., Wassing, R., Houtman, S. J., Bresser, T., Blanken, T. F., Te Lindert, B., Ramautar, J. R., & Van Someren, E. J. W. (2020). Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial. BMC Psychiatry, 20(1), 163. https://doi.org/10.1186/s12888-020-02554-8

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title = "Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial",

abstract = "BACKGROUND: Major depressive disorder is among the most burdening and costly chronic health hazards. Since its prognosis is poor and treatment effectiveness is moderate at best, prevention would be the strategy of first choice. Insomnia may be the best modifiable risk factor. Insomnia is highly prevalent (4-10%) and meta-analysis estimates ±13% of people with insomnia to develop depression within a year. Among people with insomnia, recent work identified three subtypes with a particularly high lifetime risk of depression. The current randomized controlled trial (RCT) evaluates the effects of internet-guided Cognitive Behavioral Therapy for Insomnia (CBT-I), Chronobiological Therapy (CT), and their combination on insomnia and the development of depressive symptoms.METHODS: We aim to include 120 participants with Insomnia Disorder (ID) of one of the three subtypes that are more prone to develop depression. In a two by two factorial repeated measures design, participants will be randomized to CBT-I, CT, CBT-I + CT or treatment as usual, and followed up for one year. The primary outcome is the change, relative to baseline, of the severity of depressive symptoms integrated over four follow-ups spanning one year. Secondary outcome measures include a diagnosis of major depressive disorder, insomnia severity, sleep diaries, actigraphy, cost-effectiveness, and brain structure and function.DISCUSSION: Pre-selection of three high-risk insomnia subtypes allows for a sensitive assessment of the possibility to prevent the development and worsening of depressive symptoms through interventions targeting insomnia.TRIAL REGISTRATION: Netherlands Trial Register (NL7359). Registered on 19 October 2018.",

author = "Jeanne Leerssen and Foster-Dingley, {Jessica C} and Oti Lakbila-Kamal and Dekkers, {Laura M S} and Albers, {Anne C W} and Ikelaar, {Savannah L C} and Teodora Maksimovic and Rick Wassing and Houtman, {Simon J} and Tom Bresser and Blanken, {Tessa F} and {Te Lindert}, Bart and Ramautar, {Jennifer R} and {Van Someren}, {Eus J W}",

year = "2020",

doi = "10.1186/s12888-020-02554-8",

language = "English",

volume = "20",

pages = "163",

journal = "BMC Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central",

number = "1",

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Leerssen, J, Foster-Dingley, JC, Lakbila-Kamal, O, Dekkers, LMS, Albers, ACW, Ikelaar, SLC, Maksimovic, T, Wassing, R, Houtman, SJ, Bresser, T, Blanken, TF, Te Lindert, B, Ramautar, JR & Van Someren, EJW 2020, 'Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial', BMC Psychiatry, vol. 20, nr. 1, blz. 163. https://doi.org/10.1186/s12888-020-02554-8

Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial. / Leerssen, Jeanne; Foster-Dingley, Jessica C; Lakbila-Kamal, Oti et al.
In: BMC Psychiatry, Vol. 20, Nr. 1, 2020, blz. 163.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

TY - JOUR

T1 - Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes

T2 - protocol of a randomized controlled prevention trial

AU - Leerssen, Jeanne

AU - Foster-Dingley, Jessica C

AU - Lakbila-Kamal, Oti

AU - Dekkers, Laura M S

AU - Albers, Anne C W

AU - Ikelaar, Savannah L C

AU - Maksimovic, Teodora

AU - Wassing, Rick

AU - Houtman, Simon J

AU - Bresser, Tom

AU - Blanken, Tessa F

AU - Te Lindert, Bart

AU - Ramautar, Jennifer R

AU - Van Someren, Eus J W

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Major depressive disorder is among the most burdening and costly chronic health hazards. Since its prognosis is poor and treatment effectiveness is moderate at best, prevention would be the strategy of first choice. Insomnia may be the best modifiable risk factor. Insomnia is highly prevalent (4-10%) and meta-analysis estimates ±13% of people with insomnia to develop depression within a year. Among people with insomnia, recent work identified three subtypes with a particularly high lifetime risk of depression. The current randomized controlled trial (RCT) evaluates the effects of internet-guided Cognitive Behavioral Therapy for Insomnia (CBT-I), Chronobiological Therapy (CT), and their combination on insomnia and the development of depressive symptoms.METHODS: We aim to include 120 participants with Insomnia Disorder (ID) of one of the three subtypes that are more prone to develop depression. In a two by two factorial repeated measures design, participants will be randomized to CBT-I, CT, CBT-I + CT or treatment as usual, and followed up for one year. The primary outcome is the change, relative to baseline, of the severity of depressive symptoms integrated over four follow-ups spanning one year. Secondary outcome measures include a diagnosis of major depressive disorder, insomnia severity, sleep diaries, actigraphy, cost-effectiveness, and brain structure and function.DISCUSSION: Pre-selection of three high-risk insomnia subtypes allows for a sensitive assessment of the possibility to prevent the development and worsening of depressive symptoms through interventions targeting insomnia.TRIAL REGISTRATION: Netherlands Trial Register (NL7359). Registered on 19 October 2018.

AB - BACKGROUND: Major depressive disorder is among the most burdening and costly chronic health hazards. Since its prognosis is poor and treatment effectiveness is moderate at best, prevention would be the strategy of first choice. Insomnia may be the best modifiable risk factor. Insomnia is highly prevalent (4-10%) and meta-analysis estimates ±13% of people with insomnia to develop depression within a year. Among people with insomnia, recent work identified three subtypes with a particularly high lifetime risk of depression. The current randomized controlled trial (RCT) evaluates the effects of internet-guided Cognitive Behavioral Therapy for Insomnia (CBT-I), Chronobiological Therapy (CT), and their combination on insomnia and the development of depressive symptoms.METHODS: We aim to include 120 participants with Insomnia Disorder (ID) of one of the three subtypes that are more prone to develop depression. In a two by two factorial repeated measures design, participants will be randomized to CBT-I, CT, CBT-I + CT or treatment as usual, and followed up for one year. The primary outcome is the change, relative to baseline, of the severity of depressive symptoms integrated over four follow-ups spanning one year. Secondary outcome measures include a diagnosis of major depressive disorder, insomnia severity, sleep diaries, actigraphy, cost-effectiveness, and brain structure and function.DISCUSSION: Pre-selection of three high-risk insomnia subtypes allows for a sensitive assessment of the possibility to prevent the development and worsening of depressive symptoms through interventions targeting insomnia.TRIAL REGISTRATION: Netherlands Trial Register (NL7359). Registered on 19 October 2018.

U2 - 10.1186/s12888-020-02554-8

DO - 10.1186/s12888-020-02554-8

M3 - Article

C2 - 32293363

SN - 1471-244X

VL - 20

SP - 163

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

ER -

Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial

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