TY - JOUR
T1 - Intestinal Regeneration
T2 - Regulation by the Microenvironment
AU - Hageman, Joris H
AU - Heinz, Maria C
AU - Kretzschmar, Kai
AU - van der Vaart, Jelte
AU - Clevers, Hans
AU - Snippert, Hugo J G
N1 - Copyright © 2020 Elsevier Inc. All rights reserved.
PY - 2020/8/24
Y1 - 2020/8/24
N2 - Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through dedifferentiation. The microenvironment modulates this regenerative response by influencing the activity of signaling pathways, including Wnt, Notch, and YAP/TAZ. For instance, mesenchymal cells and immune cells become more abundant after damage and secrete signaling molecules that promote the regenerative process. Furthermore, regeneration is influenced by the nutritional state, microbiome, and extracellular matrix. Here, we review how all these components cooperate to restore epithelial homeostasis in the intestine after injury.
AB - Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through dedifferentiation. The microenvironment modulates this regenerative response by influencing the activity of signaling pathways, including Wnt, Notch, and YAP/TAZ. For instance, mesenchymal cells and immune cells become more abundant after damage and secrete signaling molecules that promote the regenerative process. Furthermore, regeneration is influenced by the nutritional state, microbiome, and extracellular matrix. Here, we review how all these components cooperate to restore epithelial homeostasis in the intestine after injury.
U2 - 10.1016/j.devcel.2020.07.009
DO - 10.1016/j.devcel.2020.07.009
M3 - Book/Film/Article review
C2 - 32841594
SN - 1534-5807
VL - 54
SP - 435
EP - 446
JO - Developmental Cell
JF - Developmental Cell
IS - 4
ER -