Kinetochore Malfunction in Human Pathologies

Bas de Wolf; Geert J P L Kops

doi:10.1007/978-3-319-57127-0_4

Kinetochore Malfunction in Human Pathologies

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

11 Citaten (Scopus)

Samenvatting

The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper kinetochore function is therefore key in preventing aneuploidization. Mutations in genes encoding kinetochore proteins are associated with several severe developmental disorders associated with microcephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.

Originele taal-2	Engels
Pagina's (van-tot)	69-91
Aantal pagina's	23
Tijdschrift	Advances in Experimental Medicine and Biology
Volume	1002
DOI's	https://doi.org/10.1007/978-3-319-57127-0_4
Status	Gepubliceerd - 2017

Toegang tot document

10.1007/978-3-319-57127-0_4

Citeer dit

@article{cce4f2a5b8a446a0838acbe6e5d24ac2,

title = "Kinetochore Malfunction in Human Pathologies",

abstract = "The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper kinetochore function is therefore key in preventing aneuploidization. Mutations in genes encoding kinetochore proteins are associated with several severe developmental disorders associated with microcephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.",

keywords = "Aneuploidy, Animals, Chromosomal Instability, Chromosome Segregation, Genetic Predisposition to Disease, Humans, Kinetochores, Microcephaly, Mitosis, Mutation, Neoplasms, Journal Article, Review",

author = "{de Wolf}, Bas and Kops, {Geert J P L}",

year = "2017",

doi = "10.1007/978-3-319-57127-0_4",

language = "English",

volume = "1002",

pages = "69--91",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer New York",

}

TY - JOUR

T1 - Kinetochore Malfunction in Human Pathologies

AU - de Wolf, Bas

AU - Kops, Geert J P L

PY - 2017

Y1 - 2017

N2 - The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper kinetochore function is therefore key in preventing aneuploidization. Mutations in genes encoding kinetochore proteins are associated with several severe developmental disorders associated with microcephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.

AB - The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper kinetochore function is therefore key in preventing aneuploidization. Mutations in genes encoding kinetochore proteins are associated with several severe developmental disorders associated with microcephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.

KW - Aneuploidy

KW - Animals

KW - Chromosomal Instability

KW - Chromosome Segregation

KW - Genetic Predisposition to Disease

KW - Humans

KW - Kinetochores

KW - Microcephaly

KW - Mitosis

KW - Mutation

KW - Neoplasms

KW - Journal Article

KW - Review

U2 - 10.1007/978-3-319-57127-0_4

DO - 10.1007/978-3-319-57127-0_4

M3 - Article

C2 - 28600783

SN - 0065-2598

VL - 1002

SP - 69

EP - 91

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Kinetochore Malfunction in Human Pathologies

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit