Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

TY - JOUR

T1 - Leader of the SAC

T2 - molecular mechanisms of Mps1/TTK regulation in mitosis

AU - Pachis, Spyridon T

AU - Kops, Geert J P L

N1 - © 2018 The Authors.

PY - 2018/8

Y1 - 2018/8

N2 - Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the search for compounds that target essential cellular processes to eliminate, for example, tumour cells or pathogens. Research in recent decades has offered many insights into the molecular function of Mps1 and its regulation. In this review, we integrate the latest knowledge regarding the regulation of Mps1 activity and its spatio-temporal distribution, highlight gaps in our understanding of these processes and propose future research avenues to address them.

AB - Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the search for compounds that target essential cellular processes to eliminate, for example, tumour cells or pathogens. Research in recent decades has offered many insights into the molecular function of Mps1 and its regulation. In this review, we integrate the latest knowledge regarding the regulation of Mps1 activity and its spatio-temporal distribution, highlight gaps in our understanding of these processes and propose future research avenues to address them.

U2 - 10.1098/rsob.180109

DO - 10.1098/rsob.180109

M3 - Article

C2 - 30111590

SN - 2046-2441

VL - 8

JO - Open Biology

JF - Open Biology

IS - 8

ER -